Ice plant (<i>Mesembryanthemum crystallinum</i>) improves hyperglycaemia and memory impairments in a Wistar rat model of streptozotocin-induced diabetes

Lee, Bao-Hong; Lee, Chia-Chen; Wu, She–Ching

doi:10.1002/jsfa.6552

Cited by 40 publications

(30 citation statements)

References 43 publications

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“…The species Mesembryanthemum crystallinum is characterized by antioxidant and antibacterial properties and is of pharmacological and dermocosmetic interest [68]. The plant was widely used in traditional medicine for the respiratory or urinary system and has been used as an antidiabetic agent in Japan [13,69,70,71]. The pressed juice of the plant influences the cell physiology of human keratinocytes and fibroblasts and improves skin hydration in atopic patients [72,73].…”

Section: Discussionmentioning

confidence: 99%

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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Background: Dry skin reflects a skin barrier defect which can lead to atopic dermatitis. Little is known about the distinct effects of emollient use in children with dry skin and atopic predisposition. Objectives: We investigated the effects of daily application of pressed ice plant juice (PIPJ)-based emollients and petrolatum-based emollients. Methods: Children aged 2-6 years with dry skin and atopic predisposition were randomized into 2 groups: group 1 received emollients containing PIPJ and natural lipids, while group 2 received petrolatum-based emollients. Skin condition and biophysical properties of the skin barrier were assessed at inclusion and weeks 4, 12 and 16. Results: Skin condition improved significantly in all children. Comparing the groups, children treated with emollients containing PIPJ showed significantly higher stratum corneum hydration values and significantly lower transepidermal water loss values at week 16 on the forearm and forehead. A significant decrease in skin pH was noted in group 2 on the forearm and forehead; group 1 showed a stable course. Conclusion: Early intervention with emollients in children with dry skin condition and atopic predisposition may improve their skin condition during daily emollient application. PIPJ-based formulations may be helpful to maintain skin barrier integrity.

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Section: Discussionmentioning

confidence: 99%

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Schario

Lünnemann²,

Stroux³

et al. 2014

Skin Pharmacol Physiol

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“…Hyperglycemia could induce oxidative stress in the hippocampus [9] resulting in apoptosis of hippocampal synapses and neurons [10]. Hippocampal oxidative stress is associated with increased level of lipid peroxidation products [11] and diminution of activity levels of endogenous antioxidant enzymes [12].…”

Section: Introductionmentioning

confidence: 99%

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Giribabu

Srinivasarao

Rekha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.

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“…Concretamente, NIC5-15 es el pinitol, un alcohol de azúcar cíclico natural 32 . Se encuentra en la soja y en varias otras plantas y frutas.…”

Section: Inhibidores Y Moduladores De La ␥-Secretasaunclassified

“…Además, el pinitol actúa como un sensibilizador de insulina. El compuesto modula la ␥-secretasa reduciendo la producción de ␤A, mientras que no afecta la escisión del sustrato de Notch-␥-secretasa 32,33 . Se ha indicado que el compuesto mejora el déficit de la función y la memoria cognitiva en modelos preclínicos de neuropatología de la EA 33 .…”

Section: Inhibidores Y Moduladores De La ␥-Secretasaunclassified

“…Se ha indicado que el compuesto mejora el déficit de la función y la memoria cognitiva en modelos preclínicos de neuropatología de la EA 33 . Los estudios realizados en animales y ensayos en humanos han demostrado que NIC5-15 es seguro y además actúa como sensibilizador de las acciones de la insulina 32 . En estudios preclínicos en dosis superiores a las estudiadas previamente en los ensayos clínicos, se encontró que NIC5-15 interfiere con la acumulación de ␤A.…”

Section: Inhibidores Y Moduladores De La ␥-Secretasaunclassified

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Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide

et al. 2018

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Ice plant (Mesembryanthemum crystallinum) improves hyperglycaemia and memory impairments in a Wistar rat model of streptozotocin-induced diabetes

Abstract: These findings indicated that IPE and D-pinitol possess beneficial effects for neural protection and memory ability in a rat model of diabetes.

Cited by 40 publications

References 43 publications

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Children with Dry Skin and Atopic Predisposition: Daily Use of Emollients in a Participant-Blinded, Randomized, Prospective Trial

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide

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