This article focuses on the presence of humans in Siberia and the Russian Far East at the coldest time of the Late Pleistocene, called the Last Glacial Maximum (LGM) and dated to c. 20,000-18,000 rcbp. Reconstruction of the LGM environment of Siberia, based on the latest models and compilations, provides a background for human existence in this region. Most of Siberia and the Russian Far East at c. 20,000-18,000 rcbp was covered by tundra and cool steppe, with some forest formations in the river valleys. Climate was much colder and drier than it is today. Eighteen Upper Paleolithic sites in Siberia are radiocarbon dated strictly to the LGM, and at least six of them, located in southern parts of western and eastern Siberia and the Russian Far East, have solid evidence of occupation during that time span. It seems clear that southern Siberia was populated by humans even at the height of the LGM, and that there was no dramatic decline or complete disappearance of humans in Siberia at that time. The degree of human adaptation to periglacial landscapes in the mid-Upper Paleolithic of northern Eurasia was quite high; humans coped with the cold and dry environmental conditions using microblade technology, artificial shelters, tailored clothes, and megafaunal bones as fuel.