ICG Clearance Monitoring in ICU Patients

Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences

“…This was true even when long acquisition times of up to 5 s were used. This result was attributed to the rapid clearance of ICG from the blood stream, which is known to occur at a rate of approximately 18-25% per minute 11 . While IV ICG is used to visualise blood vessels in the eye in retinal angiography examinations, its fluorescence signal is known to decrease very quickly after injection.…”

“…In this case, however, the participant also provided urine samples before and 2 h after ingestion of the FITC-Dextran. (No urine samples were collected in the ICG experiments as ICG is known to be extracted from the blood stream almost exclusively via hepatic clearance 11 , suggesting that little to no ICG would be detected in urine even if it did pass the gut barrier). Fluorescence spectra recorded from the urine samples revealed a higher fluorescence intensity in the post-FITC-Dextran sample than in the pre-FITC-Dextran sample (Fig.…”

Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data

“…This study presented an automated approach to objectively and quantitatively analyse biomarker uptake and distribution from MSOT image data. We utilised and validated our approach by assessing liver function in a well-characterised murine model of sepsis-associated liver failure [16] , [24] , based on the uptake and clearance of the clinically established biomarker ICG [18] , [25] . We have shown multiple advantages of our signal-oriented approach compared to the widely used tissue-oriented analysis [7] , [8] , [9] , [10] , [11] , [12] , [13] .…”

“…peritoneal contamination and infection model (PCI) of sepsis [16] , [17] . Liver function is quantitatively assessed by MSOT imaging of the clinically approved fluorescent chromophore indocyanine green (ICG) [18] . Hepatic ICG clearance is compared between healthy animals and those subjected to PCI.…”

“…Hepatic ICG clearance is compared between healthy animals and those subjected to PCI. Since ICG is almost exclusively eliminated by the liver when administered intraveneously, its excretion is impaired by liver dysfunction under septic condition and it therefore serves as a marker for liver function [18] . Our fully automated signal-oriented analysis outperforms the tissue-oriented approach in distinguishing healthy from diseased animals and provides information about the spatial distribution of the biomarker.…”