Ichthyosis hystrix Curth–Macklin type in an African girl

Yusuf, Salim; Mijinyawa, Muhammad Sani; Maiyaki, Musa B.; Mohammed, AZ

doi:10.1111/j.1365-4632.2007.03291.x

Cited by 8 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IHCM is an autosomal dominant disorder that is characterized by palmoplantar keratoderma and hyperkeratotic, ridged or cobblestoned plaques over the large joints. 2 In this case, there was no specific histopathological change, for example, perinuclear halo or binucleated cells, 3 and no palmoplantar keratoderma was observed.…”

Section: Case Of Unilateral Epidermal Nevi Without Extracutaneous Anomentioning

confidence: 66%

Case of unilateral epidermal nevi without extracutaneous anomalies

Kitayama

Otsuka

Kaku

et al. 2016

The Journal of Dermatology

View full text Add to dashboard Cite

Dear Editor, Epidermal nevi are noted as linear tan patches or thin plaques. The linear pattern often follows Blaschko's lines, which are considered to represent patterns of epidermal migration during embryogenesis. Histologically, epidermal nevi exhibit hyperkeratosis and papillomatosis. The condition usually appears at birth or within the first year of life, but on rare occasions, it develops until later in childhood. 1 Here, we report a case of epidermal nevi limited to the right side of the body in an adult male.A 36-year-old Japanese man was referred to our department for evaluation of his unilateral dermatitis that had begun in early childhood and became significant at the age of 15 years. He was first diagnosed with atopic dermatitis and had been treated with topical steroids. He had no family history of genetic disorders. Physical examination showed a striking lateralization diffusely affecting only the right side of the body, with strict midline demarcation. The affected side exhibited ichthyosiform erythroderma partially covered with waxy and yellowish scales (Fig. 1a). He did not exhibit alopecia, neurological abnormalities, limb hypoplasia or skeletal (a) (b) (c) (d) Figure 1. Clinical manifestations and histology of the patient. (a) Ichthyosiform erythroderma partially covered with waxy and yellowish scales with striking lateralization diffusely affecting only the right side of the body with strict midline demarcation at the initial physical examination. He had mild itchy and hyperhidrosis of the right side of the body. (b) Skin biopsy from the right precordium revealed hyperkeratosis and perivascular lymphocytic infiltration (hematoxylin-eosin [HE], original magnification 940). (c,d) Skin biopsy from a thick nodule of the buttock reminiscent of psoriasis (HE, original magnifications: [c] 9100; [d] 9200).

show abstract

Section: Case Of Unilateral Epidermal Nevi Without Extracutaneous Anomentioning

confidence: 66%

Case of unilateral epidermal nevi without extracutaneous anomalies

Kitayama

Otsuka

Kaku

et al. 2016

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Although sporadic cases have been reported in the literature (Mehta et al, 2015, Yusuf et al, 2009, Brusasco et al, 1994), IHCM is typically described using Ollendorff-Curth’s original description (Ollendorff-Curth et al, 1972) as an autosomal dominant condition recurring in two families (Niemi et al, 1990, Sprecher et al, 2001). More recent genetic linkage studies have revealed that various mutations in the KRT1 gene, which encodes keratin 1, play a central role in disease pathogenesis (Fonseca et al, 2013, Ishida-Yamamoto et al, 2003, Kubo et al, 2011, Richardson et al, 2006, Sprecher et al, 2001).…”

Section: Ichthyosis Hystrix Curth-macklin Typementioning

confidence: 99%

Helen Ollendorff-Curth: A dermatologist’s lasting legacy

Guzman

James

2016

International Journal of Women's Dermatology

View full text Add to dashboard Cite

“…Ichthyosis hystrix of Curth and Macklin type is a rare autosomal dominant disorder with very few sporadic cases[3] reported since its first description in 1954. It is characterized by extensive, spiky, or verrucous, hyperkeratotic, ridged, or cobblestoned plaques over the large joints, hyperkeratotic papules on the trunk and extremities, with massive palmoplantar keratoderma leading to deep, bleeding, and painful fissures.…”

mentioning

confidence: 99%