icognition: a smartphone-based cognitive screening battery

Denissen, Stijn; Laethem, Delphine Van; Baijot, Johan; Descamps, A.; Remoortel, Ann Van; Merhaegen-Wieleman, Annick Van; D'hooghe, Marie B; D’haeseleer, Miguel; Smeets, Dirk; Sima, Diana M.; Schependom, Jeroen Van; Nagels, Guy

doi:10.1101/2023.07.19.23292824

Cited by 1 publication

(2 citation statements)

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“…Another advantage of the FDT is that it will be integrated in a holistic patient application, 9 which will assess several other functionalities such as patient-reported outcome measures (PROMs) and cognitive tests. 8 This will increase adherence, as the app holistically assesses disease impact in MS. The implementation of the FDT into daily practice poses many advantages.…”

Section: Discussionmentioning

confidence: 99%

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The Finger Dexterity Test: Validation study of a smartphone-based manual dexterity assessment

Van Laethem,

Denissen,

Costers

et al. 2023

Mult Scler

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Background: The Nine-Hole Peg Test (9HPT) is the golden standard to measure manual dexterity in people with multiple sclerosis (MS). However, administration requires trained personnel and dedicated time during a clinical visit. Objectives: The objective of this study is to validate a smartphone-based test for remote manual dexterity assessment, the icompanion Finger Dexterity Test (FDT), to be included into the icompanion application. Methods: A total of 65 MS and 81 healthy subjects were tested, and 20 healthy subjects were retested 2 weeks later. Results: The FDT significantly correlated with the 9HPT (dominant: ρ = 0.62, p < 0.001; non-dominant: ρ = 0.52, p < 0.001). MS subjects had significantly higher FDT scores than healthy subjects (dominant: p = 0.015; non-dominant: p = 0.013), which was not the case for the 9HPT. A significant correlation with age (dominant: ρ = 0.46, p < 0.001; non-dominant: ρ = 0.40, p = 0.002), Expanded Disability Status Scale (EDSS, dominant: ρ = 0.36, p = 0.005; non-dominant: ρ = 0.31, p = 0.024), and disease duration for the non-dominant hand (ρ = 0.31, p = 0.016) was observed. There was a good test–retest reliability in healthy subjects (dominant: r = 0.69, p = 0.001; non-dominant: r = 0.87, p < 0.001). Conclusions: The icompanion FDT shows a moderate-to-good concurrent validity and test–retest reliability, differentiates between the MS subjects and healthy controls, and correlates with clinical parameters. This test can be implemented into routine MS care for remote follow-up of manual dexterity.

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Section: Discussionmentioning

confidence: 99%

“…Informed consent was obtained from all participants before inclusion. This study is part of a bigger validation study of a smartphone app that assesses both cognitive performance 8 and manual dexterity in PwMS, to be included into the icompanion app. 9…”

Section: Methodsmentioning

confidence: 99%