ICPBCZin: A red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions

Roussakis, Emmanuel; Voutsadaki, Styliani; Pinakoulaki, Eftychia; Sideris, Dionisia P.; Tokatlidis, Kostas; Katerinopoulos, Haralambos E.

doi:10.1016/j.ceca.2007.12.008

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…In another study, a large zinc-induced emission spectral shift in the visible region was observed for the furoquinoline-based system FQ1 ( 8 , Figure 1), although with limited water solubility and metal selectivity [28]. Finally, the red emitting indicator ICPBCZin ( 9 , Figure 1) containing an iminodiacetate binding unit reported zinc concentration changes in the nanomolar range with with an ipsochromic shift and a decrease in emission intensity [29]. …”

Section: Fluorescent Small-molecule Sensorsmentioning

confidence: 99%

Imaging mobile zinc in biology

Tomat

Lippard

2010

Current Opinion in Chemical Biology

202

114

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SummaryTrafficking and regulation of mobile zinc pools influence cellular functions and pathological conditions in multiple organs, including brain, pancreas, and prostate. The quest for a dynamic description of zinc distribution and mobilization in live cells fuels the development of increasingly sophisticated probes. Detection systems that respond to zinc binding with changes of their fluorescence emission properties have provided sensitive tools for mobile zinc imaging, and fluorescence microscopy experiments have afforded depictions of zinc distribution within live cells and tissues. Both small-molecule and protein-based fluorescent probes can address complex imaging challenges, such as analyte quantification, site-specific sensor localization, and real-time detection.

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Section: Fluorescent Small-molecule Sensorsmentioning

confidence: 99%

Imaging mobile zinc in biology

Tomat

Lippard

2010

Current Opinion in Chemical Biology

202

114

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“…Thus dyes 1, 2 and 3 seem to fulfill most of the criteria required for intracellular lead indicators, as they exhibit high selectivity for Pb 2+ , they are excited in the visible region shifting their maxima upon binding allowing for ratiometric measurements, and they can be converted into cell permeable derivatives, as we showed in a recent work for those systems, 13 by modifying their carboxylate moieties to the corresponding acetoxymethyl esters.…”

mentioning

confidence: 62%

“…Structure-wise all three probes share the N-(2-methoxyphenyl)iminodiacetic acid (2-[(carboxymethyl)(2-methoxyphenyl)amino]acetic acid) moiety, as ionophore. According to recent data from our laboratory, 13 these systems were expected to function as visible-excited ratiometric probes and interact with high affinity for zinc ions. However, these dyes proved to be selective for lead ions.…”

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confidence: 99%

Coumarin-based ratiometric fluorescent indicators with high specificity for lead ions

2008

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“…The quantity of zinc would affect the function of the proteins and enzymes concerning neural signal transmission, DNA reproduction, RNA transfer and other catalytic reaction [3][4][5]. So the abnormity of zinc quantity would be involved in neurological disorders such as Parkinson' disease and epilepsy [6]. In addition, zinc has strong relationship to immune system, endocrine system and gastroenterological systems [7].…”

Section: Introductionmentioning

confidence: 99%