ICSI for non-male factor infertility: time to reappraise IVF?

SALLAM, Hassan; Boitrelle, Florence; Palini, Simone; Durairajanayagam, Damayanthi; Parmegiani, Lodovico; Jindal, Sunil; Saleh, Ramadan; Colpi, Giovanni M.; Agarwal, Ashok

doi:10.23736/s0031-0808.23.04869-3

Cited by 4 publications

(1 citation statement)

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“…re‐evaluates the use of ICSI in the context of non‐male factor infertility, suggesting a nuanced understanding of its benefits beyond conventional use, thereby broadening the horizon of its applicability in ART. 177 These studies underscore the continued evolution and critical impact of ICSI in reproductive medicine, confirming its status as a transformative technology in ART.…”

Section: Prospects For Icsimentioning

confidence: 73%

Evolution of intracytoplasmic sperm injection: From initial challenges to wider applications

Asada

2024

Reprod Medicine & Biology

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BackgroundIn vitro fertilization (IVF) has revolutionized infertility treatment. Nevertheless, male infertility requires more effective solutions. In 1992, the first‐ever case of human birth via intracytoplasmic sperm injection (ICSI) was reported. ICSI involves microscopically injecting a sperm into an ovum. Successful ICSI has become a reliable therapy for couples facing infertility, a significant milestone. However, it has also introduced various challenges. This study also delves into ethical dilemmas arising from widespread ICSI use.MethodsThis review traces the history of ICSI, presenting pioneering attempts, first successful attempts, and critical reports on account of the initial skepticism toward the technology. The review also focuses on chronological progress until ICSI was recognized as effective and became widely applied.Main findingsThe review reveals that ICSI, although transformative, presents challenges. Successes include addressing male infertility and aiding fertilization. However, concerns arise regarding optimal sperm and embryo selection, genetic mutations, and long‐term health implications. Ethical considerations surrounding ICSI's broad applications also surface.ConclusionsDespite its success and effectiveness, ICSI is still evolving as a therapeutic method. By comprehensively evaluating the historical progress and the current status of ICSI and exploring its future prospects, this study highlights the importance of ICSI in infertility treatment.

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Section: Prospects For Icsimentioning

confidence: 73%