Summary: Symptomatic occipital lobe epilepsy is increasingly recognized among patients with partial-onset seizures. Although traditional clinical and electroencephalographic criteria had defined occipital lobe epilepsy in the past, new neuroimaging techniques and the recognition of specific syndromes associated with occipital lobe epilepsy have improved the diagnosis and management of these patients. These syndromes include, among others, lesional occipital lobe epilepsy (congenital vs. acquired), MELAS, and epilepsy with bilateral occipital calcifications. The diagnosis of symptomatic occipital lobe epilepsy is improving as functional and structural neuroimaging techniques enable the detection of subtle abnormalities in such patients. This has had a direct impact on the correct classification of patients with benign occipital lobe epilepsy, basilar migraine, and symptomatic occipital lobe epilepsy. The common clinical symptoms, EEG patterns, and neuroimaging findings of these patients are discussed. Key Words: Occipital lobe epilepsy-congenital vs. acquired syndromes-EEG patterns-Neuroimaging.Advances in the diagnosis of epilepsy have led to refinements in the classification of the epilepsies. This has been primarily possible because of recent major advances in neuroimaging techniques, which are now able to detect pathology in many patients with temporal lobe epilepsy, particularly in those with mesial temporal lobe sclerosis. This capability, in addition to the wealth of new noninvasive imaging techniques, has directed efforts toward the better definition of extratemporal lobe epilepsies. This article describes the clinical features associated with symptomatic occipital lobe epilepsy and reviews the etiologic factors, imaging and electrographic characteristics, and outcome.
EPIDEMIOLOGIC ASPECTSThe relative incidence of symptomatic occipital lobe epilepsy is unknown (1). No prospective studies are available, and most retrospective series have selected patients on the basis of EEG abnormalities or of EEG and clinical features suggestive of occipital lobe epilepsy, and have included those with benign syndromes. Furthermore, previous studies have included children and adults and have been influenced by the referral patterns of the reporting centers. An EEG-based survey reported 8% of the population as having occipital seizures. An Italian study (2) reported that occipital epilepsy consti- tuted 11% of symptomatic partial epilepsies in children.Other centers report frequencies ranging from 4 to 13%.In contrast, data from epilepsy surgery centers suggest that occipital lobe resections constitute less than 5% of operated patients (3). The available data, however, are an underestimation of the relative frequency of occipital seizures. This is a reflection of the fact that a sizable number of patients with occipital lobe epilepsy are not correctly diagnosed or are not candidates for epilepsy surgery.
CLINICAL SYMPTOMS OF OCCIPITAL LOBE EPILEPSYThe symptomatology of occipital lobe epilepsy was described as early as 188...