Ictal PET in presurgical workup of refractory extratemporal epilepsy

Nooraine, Javeria; Iyer, Rajesh B; Raghavendra, S.

doi:10.4103/0972-2327.120475

Cited by 3 publications

(1 citation statement)

References 2 publications

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“…Gamma-aminobutyric acid (GABA) is the most important inhibitory neurotransmitter in the central nervous system. 40 - 43 Its main role consists of reducing neuronal excitability and regulating muscle tone. There are two types of GABA receptors: GABA A and GABA B ; benzodiazepine receptors are modulatory sites on GABA A receptors.…”

Section: F- Flumazenil Tracers For Pet/ct Of Patients Witmentioning

confidence: 99%

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy

Hodolič¹,

Topakian

Pichler

2016

Radiology and Oncology

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BackgroundEpilepsy is a neurological disorder characterized by epileptic seizures as a result of excessive neuronal activity in the brain. Approximately 65 million people worldwide suffer from epilepsy; 20–40% of them are refractory to medication therapy. Early detection of disease is crucial in the management of patients with epilepsy. Correct localization of the ictal onset zone is associated with a better surgical outcome. The modern non-invasive techniques used for structural-functional localization of the seizure focus includes electroencephalography (EEG) monitoring, magnetic resonance imaging (MRI), single photon emission tomography/computed tomography (SPECT/CT) and positron emission tomography/computed tomography (PET/CT). PET/CT can predict surgical outcome in patients with refractory epilepsy. The aim of the article is to review the current role of routinely used tracer 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) as well as non routinely used 18F-Flumazenil (18F-FMZ) tracers PET/CT in patients with refractory epilepsy.ConclusionsFunctional information delivered by PET and the morphologic information delivered by CT or MRI are essential in presurgical evaluation of epilepsy. Nowadays 18F-FDG PET/CT is a routinely performed imaging modality in localization of the ictal onset zone in patients with refractory epilepsy who are unresponsive to medication therapy. Unfortunately, 18F-FDG is not an ideal PET tracer regarding the management of patients with epilepsy: areas of glucose hypometabolism do not correlate precisely with the proven degree of change within hippocampal sclerosis, as observed by histopathology or MRI. Benzodiazepine-receptor imaging is a promising alternative in nuclear medicine imaging of epileptogenic focus. The use of 11C-FMZ in clinical practice has been limited by its short half-life and necessitating an on-site cyclotron for production. Therefore, 18F-FMZ might be established as one of the tracers of choice for patients with refractory epilepsy because of better sensitivity and anatomical resolution.

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Section: F- Flumazenil Tracers For Pet/ct Of Patients Witmentioning

confidence: 99%

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy

Hodolič¹,

Topakian

Pichler

2016

Radiology and Oncology

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Optimal timing of interictal FDG‐PET for epilepsy surgery: A systematic review on time since last seizure

2022

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In focal intractable epilepsy, resective surgery can be considered. In most presurgical evaluation protocols, the epileptic focus is localized with magnetic resonance imaging (MRI), routine electroencephalogram (EEG), and EEG video monitoring (EVM). When these tests are inconclusive, an interictal 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) is recommended. [1][2][3] Timing is crucial to avoid the metabolically dynamical postictal state that complicates interpretation. The epileptic focus is hypometabolic in the interictal phase and may be hypermetabolic in the ictal and postictal phase. [4][5][6][7]

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Multimodality in Functional Neuroimaging

Kassubek

Müller

Juengling

2014

Clinical Functional MRI

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Ictal PET in presurgical workup of refractory extratemporal epilepsy

Cited by 3 publications

References 2 publications

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy

Optimal timing of interictal FDG‐PET for epilepsy surgery: A systematic review on time since last seizure

Multimodality in Functional Neuroimaging

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Ictal PET in presurgical workup of refractory extratemporal epilepsy

Cited by 3 publications

References 2 publications

18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy

18F-fluorodeoxyglucose and 18F-flumazenil positron emission tomography in patients with refractory epilepsy

Optimal timing of interictal FDG‐PET for epilepsy surgery: A systematic review on time since last seizure

Multimodality in Functional Neuroimaging

Contact Info

Product

Resources

About

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy

¹⁸F-fluorodeoxyglucose and ¹⁸F-flumazenil positron emission tomography in patients with refractory epilepsy