Ictère grave du nouveau-né. Définition et prise en charge

Labrune, P

doi:10.1016/s0929-693x(99)80019-0

Cited by 8 publications

(2 citation statements)

References 17 publications

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“…The relatively high frequency of jaundice during the neonatal period is related to the physiological peculiarities of the newborn which may be due to polycythemia, hyperhaemolysis and hepatic immaturity [5] [6] [7].…”

Section: Introductionmentioning

confidence: 99%

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Bowassa¹,

Ngono²,

Ngakengni³

et al. 2019

OJPed

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Introduction: Jaundice is a major symptom during neonatal time. It is defined by a bilirubin ≥ 50 mg/l. Objectives: To determine the frequency of neonatal jaundice at the Brazzaville University Hospital, to determine the main etiologies, to evaluate the management, to specify the evolution. Patients and Method: It was a prospective and descriptive study that was conducted in the . It included newborn children admitted into the neonatal unit for treatment of jaundice. The variables studied were epidemiological, clinical, etiological therapy and outcome. Results: The frequency of the neonatal jaundice is 7.2%. The hyperbilirubinemia as not conjugated was found in 99.1% of cases. The main causes are bacterial neonatal infection n = 102 (47.9%), the physiological icterus n = 46 (21.6%) and the ABO incompatibility n = 40 (18.8%). The treatment consists of the phototherapy in all cases. Each phototherapy session lasts 3 hours n = 99 (56.9%), 6 hours n = 58 (33.3%) and 12 hours n = 17 (9.8%). The average duration of the administering of the therapy is of 3 ± 2 days. Hyperbilirubinemia encephalopathy occurred in 62 (29.1%) cases, including 49 cases of kernicterus. The death occurred in 70 (32.9%) children. Conclusion: The importance and the gravity of the neonatal jaundice require primary preventive means based on proper care in pregnancy and the birth. While the secondary prevention includes high index of suspicion, comprehensive diagnostic equipment availability to prevent acute bilirubin encephalopathy.

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Section: Introductionmentioning

confidence: 99%

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Bowassa¹,

Ngono²,

Ngakengni³

et al. 2019

OJPed

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show abstract

“…This condition occurs primarily in neonates (infants and newborns) and may rarely occur in adults [ 1 ]. Neonatal jaundice is easily treatable with phototherapy, albumin infusion, or exchange transfusion [ 2 , 3 ]. However, the damage inflicted on the brain by bilirubin is not always reversible and can result in cerebral palsy, deafness or hearing loss, impairment of upward gaze, and enamel dysplasia of the primary teeth [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Brain Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Findings of Children with Kernicterus

et al. 2015

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SummaryBackgroundThe term kernicterus, or bilirubin encephalopathy, is used to describe pathological bilirubin staining of the basal ganglia, brain stem, and cerebellum, and is associated with hyperbilirubinemia. Kernicterus generally occurs in untreated hyperbilirubinemia or cases where treatment is delayed. Magnetic resonance imaging (MRI)-based studies have shown characteristic findings in kernicterus. The objective of our study was to describe the role of 1H magnetic resonance spectroscopy (MRS) in demonstrating these metabolic changes and to review conventional MRI findings of kernicterus.Material/MethodsForty-eight pediatric cases with kernicterus were included in this study. MRI and MRS examinations were performed on variable dates (10–29 days after birth). NAA, Cr, Cho, NAA/Cr, NAA/Cho, and Cho/Cr values were evaluated visually and by computer analysis.ResultsThere was no statistically significant difference between the NAA and Cho levels in the acute kernicterus patients and the control group (healthy patients), whereas both were significantly elevated in the chronic kernicterus patients. Both the mean NAA/Cr and Cho/Cr ratio values were significantly higher in the acute and chronic cases compared to the control group. The NAA/Cho ratio value was statistically lower in the acute cases than in the control group while it was similar in the chronic cases.ConclusionsConventional MR imaging and 1H-MRS are important complementary tools in the diagnostics of neonatal bilirubin encephalopathy. This study provided important information for applying these MR modalities in the evaluation of neonates with bilirubin encephalopathy.

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Hyperbilirubinémies néonatales

Myara

2006

Bio trib. mag.

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Ictère grave du nouveau-né. Définition et prise en charge

Cited by 8 publications

References 17 publications

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Jaundice in the Newborn at the Teaching Hospital of Brazzaville

Brain Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy Findings of Children with Kernicterus

Hyperbilirubinémies néonatales

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