Ictogenesis of viral pneumonia: A comparison between SARS-CoV-2 and H1N1/H3N2

Milano, Chiara; Turco, Francesco; Pizzanelli, Chiara; Pascazio, Alessia; Tagliaferri, Enrico; Nesti, Lorenzo; Pistello, Mauro; Capria, Anna Lisa; Menichetti, Francesco; Forfori, Francesco; Bonanni, Enrica; Siciliano, Gabriele

doi:10.1016/j.yebeh.2021.108470

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Milano et al reported three cases of influenza pneumonia with neurological complications, in which patients were managed with medication use, tracheotomy, and high-flow oxygen therapy. Patient one had diffuse delta waves and mild chronic leukoencephalopathy, patient two had sharp delta activity on the left-T region with bilateral spreading and severe cortical atrophy and moderate chronic leukoencephalopathy, and patient three had interictal delta waves on the right F-T regions [ 33 ].…”

Section: Reviewmentioning

confidence: 99%

Exploring the Correlation Between Influenza A Virus (H3N2) Infections and Neurological Manifestations: A Scoping Review

Reddy¹,

CA²,

Kandi³

et al. 2023

Cureus

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Influenza A virus (IAV), particularly the H3N2 variant, is known to cause respiratory manifestations, but it can also lead to neurological complications ranging from mild symptoms like headache and dizziness to severe conditions such as encephalitis and acute necrotizing encephalopathy (ANE). In this article, the correlation between the H3N2 variant of the IAV and neurological manifestations is discussed. Additionally, prompt recognition and treatment of influenza-associated neurological manifestations are highlighted to prevent infection-related long-term complications. This review briefly discusses various neurological complications linked to IAV infections, such as encephalitis, febrile convulsions, and acute disseminated encephalomyelitis, and the potential mechanisms involved in the development of neurological complications.

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Section: Reviewmentioning

confidence: 99%

Exploring the Correlation Between Influenza A Virus (H3N2) Infections and Neurological Manifestations: A Scoping Review

Reddy¹,

CA²,

Kandi³

et al. 2023

Cureus

View full text Add to dashboard Cite

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Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

Löscher

Howe

2022

Front. Mol. Neurosci.

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Seizures are a common presenting symptom during viral infections of the central nervous system (CNS) and can occur during the initial phase of infection (“early” or acute symptomatic seizures), after recovery (“late” or spontaneous seizures, indicating the development of acquired epilepsy), or both. The development of acute and delayed seizures may have shared as well as unique pathogenic mechanisms and prognostic implications. Based on an extensive review of the literature, we present an overview of viruses that are associated with early and late seizures in humans. We then describe potential pathophysiologic mechanisms underlying ictogenesis and epileptogenesis, including routes of neuroinvasion, viral control and clearance, systemic inflammation, alterations of the blood-brain barrier, neuroinflammation, and inflammation-induced molecular reorganization of synapses and neural circuits. We provide clinical and animal model findings to highlight commonalities and differences in these processes across various neurotropic or neuropathogenic viruses, including herpesviruses, SARS-CoV-2, flaviviruses, and picornaviruses. In addition, we extensively review the literature regarding Theiler’s murine encephalomyelitis virus (TMEV). This picornavirus, although not pathogenic for humans, is possibly the best-characterized model for understanding the molecular mechanisms that drive seizures, epilepsy, and hippocampal damage during viral infection. An enhanced understanding of these mechanisms derived from the TMEV model may lead to novel therapeutic interventions that interfere with ictogenesis and epileptogenesis, even within non-infectious contexts.

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Ictogenesis of viral pneumonia: A comparison between SARS-CoV-2 and H1N1/H3N2

Cited by 2 publications

References 28 publications

Exploring the Correlation Between Influenza A Virus (H3N2) Infections and Neurological Manifestations: A Scoping Review

Exploring the Correlation Between Influenza A Virus (H3N2) Infections and Neurological Manifestations: A Scoping Review

Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

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