iCVD Polymer Thin Film Bio‐Interface‐Performance for Fibroblasts, Cancer‐Cells, and Viruses Connected to Their Functional Groups and In Silico Studies

Abstract

Thin polymer coatings are used to improve the interface between biological species and functional materials. Their interaction is significantly influenced by the functional groups and roughness of the polymer film and prediction of the interaction is thus of great interest. However, for conventional polymer films, this cannot be examined independently because of the interplay of defects, residual solvent molecules, roughness, and functional groups. Solvent‐free polymer films prepared by initiated chemical vapor deposition (iCVD) exhibit conformal, defect‐free characteristics and enable precise tailoring of the functional groups. This facilitates to isolate the contribution of functional groups on the bio‐interface performance. Consequently, in silico studies can enable a prediction of ligand interaction in anti‐viral activity for SARS‐CoV‐2 based on defined polymer and key protein structures. Furthermore, the cell viability of human fibroblasts can be traced back to the functional groups of the repeating units. For human liver cancer cell culture, it turns out that more sophisticated models are needed. The insilico‐iCVD approach can enable precise tailoring of complex polymer films optimized for the respective interfaces. In addition, this first big scan of the bio‐interface performance of iCVD films enables a solid starting point in areas like anticancer, antiviral, and biocompatibility for future studies.

Icephobic Gradient Polymer Coatings Deposited via iCVD: A Novel Approach for Icing Control and Mitigation

“…The effect of the cooling rate on drop freezing was investigated. A drop was cooled down to −20 °C at seven different cooling rates (10,15,20,25,30,40, and 50 °C/min) in cycle, one after the other. In the homopolymer pV 4 D 4 and Grad100, running continuous cooling cycles triggered the freezing of the drop each time −20 °C was reached.…”

“…Initiated chemical vapor deposition (iCVD) is a powerful one-step technique in the production of thin films from vapor precursors based on free radical polymerization . Over the last few years, iCVD has been applied in electronics, , biomaterials, , pharmaceuticals, and sensors, − establishing itself as a powerful process. Upon the emerging demand for new green policies and social attempt to shift toward environmentally friendly processes, iCVD presents an excellent solution.…”

Facile synthesis of Fe2O3, Fe2O3@CuO and WO3 nanoparticles: characterization, structure determination and evaluation of their biological activity

“…The viral adsorption mechanism was done via seeding Vero cells into a 6-well tissue culture plate at a density of (5 × 10 5 ) cells/well, then incubated for 24 h at ambient conditions. Upon reaching a confluency of > 90%, cells were treated with the tested NPs, then incubated for another 24 h. On the third day 63 , the cells were infected with 100 TCID50 of the virus until the appearance of cytopathogenic effect (CPE) 64 . Finally, viral load was determined by quantitative RT-PCR 60 , 65 .…”