1999
DOI: 10.1016/s0002-9440(10)65180-2
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Id-1 and Id-2 Are Overexpressed in Pancreatic Cancer and in Dysplastic Lesions in Chronic Pancreatitis

Abstract: Id proteins antagonize basic helix-loop-helix proteins , inhibit differentiation , and enhance cell proliferation. In this study we compared the expression of Id-1 , Id-2 , and Id-3 in the normal pancreas , in pancreatic cancer , and in chronic pancreatitis (CP). Northern blot analysis demonstrated that all three Id mRNA species were expressed at high levels in pancreatic cancer samples by comparison with normal or CP samples. Pancreatic cancer cell lines frequently coexpressed all three Ids , exhibiting a goo… Show more

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Cited by 138 publications
(129 citation statements)
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“…It has been suggested that Id-1 and Id-2 proteins may function in the bHLH-mediated inactivation of the cyclindependent kinase inhibitors, for example, p21 WAF1 , p16 INK4a and p27 KIP1 (Prabhu et al, 1997;Polsky et al, 2001;Ouyang et al, 2002b;Singh et al, 2002). In addition, Id-1 expression has been observed in small proliferating ducts and in the large ducts without dysplastic changes of chronic pancreatitis, which again indicates the proliferative potential of Id-1 (Maruyama et al, 1999). Thus, in the present study, we examined the proliferative potential of Id-1 expression in human primary pancreatic cancer by investigating the relation between its expression and the cell kinetic indices of PI and AI.…”
Section: Discussionmentioning
confidence: 96%
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“…It has been suggested that Id-1 and Id-2 proteins may function in the bHLH-mediated inactivation of the cyclindependent kinase inhibitors, for example, p21 WAF1 , p16 INK4a and p27 KIP1 (Prabhu et al, 1997;Polsky et al, 2001;Ouyang et al, 2002b;Singh et al, 2002). In addition, Id-1 expression has been observed in small proliferating ducts and in the large ducts without dysplastic changes of chronic pancreatitis, which again indicates the proliferative potential of Id-1 (Maruyama et al, 1999). Thus, in the present study, we examined the proliferative potential of Id-1 expression in human primary pancreatic cancer by investigating the relation between its expression and the cell kinetic indices of PI and AI.…”
Section: Discussionmentioning
confidence: 96%
“…Id-1 overexpression has been reported in several human primary cancers including pancreatic, breast and cervical cancers. Evidence indicates that Id-1 may be associated with an aggressive phenotype of human cancers (Maruyama et al, 1999;Langlands et al, 2000;Lin et al, 2000;Polsky et al, 2001;Schindl et al, 2001;Ouyang et al, 2002a;Wang et al, 2002). In the present study, we observed Id-1 overexpression in human pancreatic cancer and we also investigated the association between its expression and cell proliferation and apoptotic indices, tumour MVD, and clinicopathological prognostic factors in an effort to clarify its biologic role in human pancreatic cancers.…”
Section: Discussionmentioning
confidence: 99%
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“…These results suggested that Id-2 promotes neoplastic transformation of oesophageal epithelial cells. Id-2 has been shown to bind and inhibit the function of retinoblastoma protein, a tumour suppressor protein (Iavarone et al, 1994;Lasorella et al, 1996) and therefore has been implicated in tumour progression in several cancer types (Maruyama et al, 1999;Fukuma et al, 2003;Coppe et al, 2004).…”
Section: Discussionmentioning
confidence: 99%