Id: 3522576 Efficacy and Safety of Full Thickness Resection (Ftr) in the Upper Gastrointestinal Tract (Ugit): A Single Center North American Experience

Yuen, Poi Yu Sofia; Vareedayah, Ashley A.; Morales, Shannon J.; Ooka, Kohtaro; Haber, Gregory B.

doi:10.1016/j.gie.2021.03.399

Cited by 1 publication

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“…A total of 8 studies with 139 patients who underwent EFTR of UGI lesions using the FTRD were included in the analysis. One study was an international multicenter study, 17 the remainder were single centers 4,14–16,18–21 . All the studies were retrospective cohort studies.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies reporting outcomes of the single-step EFTR using FTRD were included in the meta-analysis. [14][15][16][17][18][19][20][21] The schematic diagram of study identification and selection is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…One study was an international multicenter study, 17 the remainder were single centers. 4,[14][15][16][18][19][20][21] All the studies were retrospective cohort studies. However, 3 of these studies were only reported as abstracts.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, 3 of these studies were only reported as abstracts. [19][20][21] The studies comprised a total of 51 duodenal lesions, 91 gastric lesions, and 1 esophageal lesion.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Safety and Efficacy of Endoscopic Full Thickness Resection of Upper Gastrointestinal Lesions Using a Full Thickness Resection Device

Bomman

Klair

Canakis

et al. 2022

Journal of Clinical Gastroenterology

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Introduction: Endoscopic full-thickness resection (EFTR) is a promising technique that allows for a minimally invasive resection of mucosal and submucosal lesions in the gastrointestinal (GI) tract. The data regarding the efficacy and safety of performing EFTR of upper GI lesions using a full-thickness resection device (FTRD) is limited. Hence, we performed a systematic review and meta-analysis of the studies that evaluated this technique.Methods: We performed a comprehensive systematic search of multiple electronic databases and conference proceedings that reported outcomes of EFTR using the FTRD system. The weighted pooled rates of technical success, complete (R0) resection, adverse events (AE), and residual or recurrent lesions were analyzed with 95% CI using the random effects model.Results: Eight studies with a total of 139 patients who underwent EFTR of upper GI lesions were included in the study. The pooled, weighted rate of technical success was 88.2% (95% CI: 81.4-92.7%, I 2 : 0). The R0 resection rate was 70.7% (95% CI: 62.5-77.8%, I 2 : 0). Overall AE rates were 22.1% (95% CI: 15.8-30.1%, I 2 : 0), however, most of the AEs were minor. Of the patients who had follow-up endoscopies, the residual and/or recurrent lesion rate was 6.1% (95% CI: 2.4-14.4%, I 2 : 0). Heterogeneity in the analysis was low.Conclusions: EFTR using the FTRD seems to be effective and safe with acceptable R0 resection rates and low recurrence rates. Further prospective studies are required to validate our results and to compare various modalities of endoscopic resection with this singlestep EFTR device.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, 3 of these studies were only reported as abstracts. [19][20][21] The studies comprised a total of 51 duodenal lesions, 91 gastric lesions, and 1 esophageal lesion.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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