Id1: A novel therapeutic target for patients with atherosclerotic plaque rupture

An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitro

“…Several reports revealed that Id1 is involved in the expression of VEGF, p21, and CCN1, thereby regulating EPC proliferation and the re-endothelialisation [17, 19, 27, 35]. Our study observed that transfection of Ad-Id1 into EPCs increased the release of VEGF.…”

Scutellaria Flavonoids Effectively Inhibit the Malignant Phenotypes of Non-small Cell Lung Cancer in an Id1-dependent Manner

“…It has been reported that Id1 enables lung cancer liver colonization through activation of EMT program in tumor cells and establishment of the pre-metastatic niche 34. Additionally, studies show angiogenesis is regulated by Id1 pathway in women with endometriosis and gastric cancer 35,36, but Id1 is shown up-regulated by VEGF-A, one of the most critical factors that stimulates angiogenesis, in atherosclerotic plaque rupture 37. In our study, we found that baicalin, baicalein and wogonin effectively inhibited the expression of N-cadherin, vimentin and up-regulated E-cadherin, they also decreased MVD in vivo and reduced the expression of VEGF-A in vitro and in vivo .…”

Integrated Bioinformatics Analysis Predicts the Key Genes Involved in Aortic Valve Calcification: From Hemodynamic Changes to Extracellular Remodeling

“…This hypothesis requires additional experimental studies to confirm. The importance of ID1, otherwise known as 'inhibitor of DNA binding-1', in angiogenesis is well described (Wang et al 2011). ID1 promotes endothelial progenitor cell proliferation via the PI3K/Akt/NFκB/Survivin pathway (Li et al 2012).…”