2009
DOI: 10.1091/mbc.e08-12-1185
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Id3 Is a Direct Transcriptional Target of Pax7 in Quiescent Satellite Cells

Abstract: INTRODUCTIONPax3 and Pax7 are two closely related transcription factors that are expressed in the dermomyotome, and they have been shown to be essential for generation of all fetal trunk musculature . Pax3/7-expressing dermomyotomal cells have recently been shown to give rise to skeletal muscle progenitors, termed satellite cells, in the adult (Gros et al., 2005;Kassar-Duchossoy et al., 2005;Relaix et al., 2005;Schienda et al., 2006). Satellite cells are a small population of myogenic progenitors that reside b… Show more

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Cited by 92 publications
(87 citation statements)
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References 35 publications
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“…This was consistent with previous reports (Olguin and Olwin, 2004;Zammit et al, 2006;Olguin et al, 2007). The majority of SMPs express Pax7 protein in vivo and in vitro just after isolation (Cerletti et al, 2008), but Pax7 mRNA expression is reduced substantially soon after placing SMPs in culture (Kumar et al, 2009) (Fig. 4F).…”
Section: Pax7 Does Not Induce Smp Differentiationsupporting
confidence: 93%
“…This was consistent with previous reports (Olguin and Olwin, 2004;Zammit et al, 2006;Olguin et al, 2007). The majority of SMPs express Pax7 protein in vivo and in vitro just after isolation (Cerletti et al, 2008), but Pax7 mRNA expression is reduced substantially soon after placing SMPs in culture (Kumar et al, 2009) (Fig. 4F).…”
Section: Pax7 Does Not Induce Smp Differentiationsupporting
confidence: 93%
“…Our next question was whether Pax7 prevented its own repression via inhibition of miR-206 and -486. Pax7 directly upregulates a number of repressors of myogenesis, including Id2 and Id3 (22) (Fig. 9).…”
Section: Resultsmentioning
confidence: 99%
“…−/− MEFs Sufu −/− MEFs were infected with retroviruses encoding pOZ-FlagHA-puro (Kumar et al, 2009), pOZ-GATA4-FlagHA-puro or pOZ-GATA5-FlagHApuro. Stable polyclones were selected using puromycin.…”
Section: Generation Of Gata4-or Gata5-expressing Sufumentioning
confidence: 99%
“…−/− MEFs that were infected with either pOZ-FlagHA-puro (the parental retrovirus) (Kumar et al, 2009), pOZ-GATA4-FlagHA-puro or pOZ-GATA5-FlagHA-puro were employed for ChIP as described previously (Carroll et al, 2005). Rabbit anti-FOG1 (as above), rabbit anti-HA (Santa Cruz Biotechnology, as above) or control rabbit IgG (Jackson Lab; 1:1000) was employed for ChIP.…”
Section: Sufumentioning
confidence: 99%