ID4 Is Required for Normal Ependymal Cell Development

Rocamonde, Brenda; Herranz-Pérez, Vicente; García‐Verdugo, José Manuel; Huillard, Emmanuelle

doi:10.3389/fnins.2021.668243

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…ID4 also has an effect on ventricle formation. Knockout of ID4 in mice resulted in ventricle enlargement, thinning of the ventricular wall and elongation of ependymal cells [36]. In addition, parvalbumin+ ependymal cells were found localized in the adhesions of the medial and lateral walls of the rostral LVs and showed a reactive phenotype during aging.…”

Section: Ventricle Shapingmentioning

confidence: 99%

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System

Deng¹,

Lin²,

Liu³

et al. 2022

Aging and disease

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Ependymal cells are indispensable components of the central nervous system (CNS). They originate from neuroepithelial cells of the neural plate and show heterogeneity, with at least three types that are localized in different locations of the CNS. As glial cells in the CNS, accumulating evidence demonstrates that ependymal cells play key roles in mammalian CNS development and normal physiological processes by controlling the production and flow of cerebrospinal fluid (CSF), brain metabolism, and waste clearance. Ependymal cells have been attached to great importance by neuroscientists because of their potential to participate in CNS disease progression. Recent studies have demonstrated that ependymal cells participate in the development and progression of various neurological diseases, such as spinal cord injury and hydrocephalus, raising the possibility that they may serve as a potential therapeutic target for the disease. This review focuses on the function of ependymal cells in the developmental CNS as well as in the CNS after injury and discusses the underlying mechanisms of controlling the functions of ependymal cells.

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Section: Ventricle Shapingmentioning

confidence: 99%

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System

Deng¹,

Lin²,

Liu³

et al. 2022

Aging and disease

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“…Since TF expressions are tightly linked to cell fate determination, we next focused on TFs exhibiting differential expression patterns between the two branches. Among the 311 TFs specifically expressed or up-regulated in nEPCs ( Figure 4C ), Foxj1 [46–49], Foxn4 [50], Rfx2 [48, 51], Rfx3 [49, 51], Myb [52], Trp73 [53], Six3 [54], Lhx2 [55, 56] and Id4 [57] have been reported to play roles in EPC production or multiciliogenesis. Here, our data uncovered these known EPC-fate regulators could be classified into two categories based on their expression profiles along the bifurcating trajectory.…”

Section: Resultsmentioning

confidence: 99%

“…Lhx2 [55,56] and Id4 [57] have been reported to play roles in EPC production or multiciliogenesis. Here, our data uncovered these known EPC-fate regulators could be classified into two categories based on their expression profiles along the bifurcating trajectory.…”

Section: Transcription Factors Important For the Nepc Fate Commitment...mentioning

confidence: 99%

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular Zone

Zheng,

Chen,

et al. 2024

Preprint

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The ventricular zone (VZ) is made up of adult neural stem cells (NSCs) and multi-ciliated ependymal cells (EPCs). Both NSCs and EPCs are derived from radial glial cells (RGCs). To date, the transcriptomic dynamics and the molecular mechanisms guiding the cell fate commitment during the differentiation remain poorly understood. In this study, we analysed the developing VZ at the single-cell resolution and identified three distinct cellular states of RGCs: bipotent glial progenitor cells (bGPCs), neonatal NSC-neuroblasts (nNSC-NBs) and neonatal EPCs (nEPCs). The differentiation from bGPCs to nNSC-NBs and nEPCs forms a continuous bifurcating trajectory. Further molecular analysis along the NSC branch unveiled a novel intermediate state of cells expressing oligodendrocyte precursor cell (OPC) and neuroblast (NB) marker genes. Several transcription factors (TFs) were proved to be essential for the EPC-lineage differentiation, with TFEB emerging as a key regulator dictating the bGPC fate. The activation of TFEB promoted differentiation towards NSC-NBs while restrained the trajectory towards EPCs. Our findings offer detailed insights into further understanding VZ development and lay the groundwork for investigating potential therapeutic strategies against VZ-related disorders, such as hydrocephalus and neurodegenerative diseases (NDDs).

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“…Decreased number and delayed maturation of ECs may disrupt CSF flow dynamics during early brain development and, consequently, enhance the accumulation of CSF within the brain ventricles, resulting in hydrocephalus [ 40 ]. Furthermore, CSF flow dynamics can affect the proliferation of neural stem cells and the migration of neuroblasts towards the olfactory bulb [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies

Mokhtar

Sayed

Zaccone

et al. 2022

Cells

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This study was conducted on 16 adult specimens of molly fish (Poecilia sphenops) to investigate ependymal cells (ECs) and their role in neurogenesis using ultrastructural examination and immunohistochemistry. The ECs lined the ventral and lateral surfaces of the optic ventricle and their processes extended through the tectal laminae and ended at the surface of the tectum as a subpial end-foot. Two cell types of ECs were identified: cuboidal non-ciliated (5.68 ± 0.84/100 μm2) and columnar ciliated (EC3.22 ± 0.71/100 μm2). Immunohistochemical analysis revealed two types of GFAP immunoreactive cells: ECs and astrocytes. The ECs showed the expression of IL-1β, APG5, and Nfr2. Moreover, ECs showed immunostaining for myostatin, S100, and SOX9 in their cytoplasmic processes. The proliferative activity of the neighboring stem cells was also distinct. The most interesting finding in this study was the glia–neuron interaction, where the processes of ECs met the progenitor neuronal cells in the ependymal area of the ventricular wall. These cells showed bundles of intermediate filaments in their processes and basal poles and were connected by desmosomes, followed by gap junctions. Many membrane-bounded vesicles could be demonstrated on the surface of the ciliated ECs that contained neurosecretion. The abluminal and lateral cell surfaces of ECs showed pinocytotic activities with many coated vesicles, while their apical cytoplasm contained centrioles. The occurrence of stem cells in close position to the ECs, and the presence of bundles of generating axons in direct contact with these stem cells indicate the role of ECs in neurogenesis. The TEM results revealed the presence of neural stem cells in a close position to the ECs, in addition to the presence of bundles of generating axons in direct contact with these stem cells. The present study indicates the role of ECs in neurogenesis.

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ID4 Is Required for Normal Ependymal Cell Development

Cited by 4 publications

References 20 publications

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System

Unraveling Lineage Roadmaps and Cell Fate Determinants to Postnatal Neural Stem Cells and Ependymal cells in the Developing Ventricular Zone

Ependymal and Neural Stem Cells of Adult Molly Fish (Poecilia sphenops, Valenciennes, 1846) Brain: Histomorphometry, Immunohistochemical, and Ultrastructural Studies

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