Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

García-Hermoso, António; Hackney, Anthony C.; Ramírez‐Vélez, Robinson

doi:10.1371/journal.pone.0185908

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…What is the mechanism beyond elevation of liver enzymes among patients with MS. It seems that accumulation of fat in hepatocyte is associated [17,18] with picture of NAFLD particularly with hypertriglyceridemia, diabetes and obesity results in hepatocyte oxidative stress and injury and a sort of inflammation within the liver tissue [19] and in our study these conclusions were reinforced by higher prevalence of MS (42.4%) among subjects with elevated ALT (the most specific liver enzyme) when compared with AST and ALP. This have been also reported in some studies [14,[20][21][22].…”

Section: Discussionsupporting

confidence: 54%

Relationship between Elevated Liver enzymes and Metabolic syndrome among Egyptian adults

Salama

Emara

Eldeep

2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aim: Liver enzymes are important markers for hepatocyte damage. Metabolic syndrome (MS) is a combination of metabolic abnormalities including high blood glucose, obesity, hypertension and dyslipidemia. The incidence of MS is believed to be increasing in Egypt. The purpose of this study is to examine the relationship between elevated liver enzymes and MS among Egyptian adults. Patients and Methods: A total 138 apparently healthy subjects were randomly included (99 females and 39 males). Demographic, clinical (blood pressure, body mass index and waist circumference) and biochemical (measurements of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lipid profile, blood glucose and viral markers) were collected from every subject. Metabolic syndrome was defined according to a well-known criteria and subjects in the final analysis were divided into group I; metabolic syndrome and group II; non-metabolic syndrome subjects. Results: In this study, 92 persons fulfilled three of the five criteria of metabolic syndrome (group I) with prevalence of 66.7% while group II (non-metabolic syndrome) represented 33.3%. Patients with MS were older and less physically active in comparison with group II. There were an association between elevations in liver enzymes (ALT, AST, ALP) and MS. ALT, AST and ALP were elevated in 42.4%, 17.2% and 20.7% of patients with MS respectively. ALT and AST showed positive correlation with elevated blood glucose and triglycerides levels while AST/ALT ratio showed negative correlation with diastolic blood pressure, triglycerides level and waist circumference. The more items of MS the patient have the higher the level of liver enzymes. Conclusion: Among Egyptian adults elevated levels of liver enzymes were associated with MS and a correlation was noticed with its components.

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Section: Discussionsupporting

confidence: 54%

Relationship between Elevated Liver enzymes and Metabolic syndrome among Egyptian adults

Salama

Emara

Eldeep

2019

Afro-Egyptian Journal of Infectious and Endemic Diseases

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“…Many epidemiological studies have used ALT and AST levels as measures to assess fat accumulation in hepatocytes. Increased ALT levels were associated with a higher likelihood of obesity, hypertension, hypertriglyceridemia, elevated blood glucose, and cardiovascular disease [ 15 , 25 , 26 ]. Furthermore, recent studies have reported the association of serum ALT and AST levels with MS [ 27 ] and its components [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Serum Liver Enzymes and Metabolic Syndrome in Korean Adults

Kim

Han

2018

IJERPH

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The purpose of this study was to evaluate the association between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and metabolic syndrome (MS) in the Korean population. A total of 11,587 adults ≥30 years of age and with complete data were selected from Korea National Health and Nutrition Examination Survey VI conducted from 2013 to 2015. Normal ALT and AST levels were divided into quartiles, and their associations with MS were assessed by logistic regression analysis. Elevated levels of ALT [adjusted odds ratio (aOR) = 7.90, 95% confidence interval (CI) = 6.50–9.60] and AST (aOR = 3.81, 95% CI = 3.10–4.74) were both significantly associated with a higher prevalence of MS. The quartile group containing the highest levels of ALT and AST within the normal range also showed an increased risk of MS and its components. Elevated levels of ALT and AST, even within the normal range, were associated with prevalence of MS.

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“…Finally, the participants were categorized into 1 of 3 health levels based on the number of CVH metrics in the ideal range that they exhibited: the healthiest level (favorable ideal CVH score) was defined as having between 5 and 7 metrics in the ideal range; the intermediate level, 3 to 4 metrics; and the unfavorable level, 0 to 2 metrics. These cut-off points have been used in prior international studies [33].…”

Section: Methodsmentioning

confidence: 99%

Muscle Fitness to Visceral Fat Ratio, Metabolic Syndrome and Ideal Cardiovascular Health Metrics

et al. 2018

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This study aimed to investigate the association between the muscle fitness to visceral fat level (MVF) ratio and the prevalence of metabolic syndrome (MetS) and ideal cardiovascular health (CVH) metrics among college students. A total of 1467 young adults recruited from the FUPRECOL study (Asociación de la Fuerza Prensil con Manifestaciones Tempranas de Riesgo Cardiovascular en Jóvenes y Adultos Colombianos), were categorized into four quartiles based on their MVF ratio. Muscular fitness was assessed using a digital handgrip dynamometer and visceral fat level was determined through bioelectrical impedance analysis. Ideal CVH was assessed, including lifestyle characteristics, anthropometry, blood pressure, and biochemical parameters. The body weight, waist circumference, body mass index (BMI), fat mass, fat mass index, and visceral fat level were significantly higher in subjects in Q1 (lower MVF ratio) than those in Q2, Q3, or Q4 (p < 0.001). The muscle fitness (handgrip and normalized grip strength (NGS)) of the subjects in Q4 was significantly greater than that of those in Q1 to Q2 (p < 0.001). Subjects with a medium-high MVF ratio (i.e., 3–4th quartiles) had an odds ratio of 2.103 of ideal CVH metrics after adjusting for age, gender, university, and alcohol intake (95% confidence interval (CI) 1.832 to 2.414; p < 0.001). A lower MVF ratio is associated with worse CVH metrics and a higher prevalence of MetS in early adulthood, supporting the hypothesis that the MVF ratio could be used as a complementary screening tool that could help clinicians identify young adults with unfavorable levels of CVH and metabolic risk.

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Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

Cited by 5 publications

References 52 publications

Relationship between Elevated Liver enzymes and Metabolic syndrome among Egyptian adults

Relationship between Elevated Liver enzymes and Metabolic syndrome among Egyptian adults

Association between Serum Liver Enzymes and Metabolic Syndrome in Korean Adults

Muscle Fitness to Visceral Fat Ratio, Metabolic Syndrome and Ideal Cardiovascular Health Metrics

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