IDEAS internal contamination database: a compilation of published internal contamination cases. A tool for the internal dosimetry community

Hurtgen, C.; Andrási, A.; Bailey, Michael R.; Blanchardon, E.; Berkovski, V.; Castellani, C. M.; Doerfel, H.; Jourdain, Jean-René; LeGuen, B.; Малатова, И.; Marsh, J. Wallis; Puncher, M.

doi:10.1093/rpd/ncl124

Cited by 16 publications

(8 citation statements)

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“…However, by following the step-by-step procedure defined by and given Doerfel et al (2006), it was possible to obtain good fits to measurements of material retained in the lung for an unusually long time.…”

Section: Resultsmentioning

confidence: 99%

“…Step 2: Select and process data As noted elsewhere Doerfel et al 2006), the transit time through the GI tract is subject to large inter-(and intra-) subject variations and is more like "slug" flow than the exponentially cleared compartments specified in ICRP Publication 30 (ICRP 1979). As a result, it is better to consider cumulative excretion over the first few days, rather than each day individually.…”

Section: Assessment Of Casementioning

confidence: 99%

“…This value is used to determine whether the predictions of the biokinetic model used to assess the intake and dose are inconsistent with the data, and to compare the fits obtained using various parameter values. In the absence of other information, the default uncertainty values and distributions suggested by Doerfel et al (2006) were used. Whole body, urine, and fecal measurements were therefore assumed to be distributed lognormally with geometric standard deviations of 1.2, 1.8, and 3, respectively.…”

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

“…Doerfel et al (2006) recommend determining the "effective" AMAD for relatively insoluble materials if data are available that represent the initial amounts deposited in the upper and lower respiratory tract. For example, the ratio of cumulative fecal excretion over the first 3 d to the lung retention on day 3 is approximately equal to the initial amount deposited in the upper respiratory tract divided by the initial amount deposited in the lower respiratory tract.…”

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

“…The main value of applying the "effective" AMAD to an assessment is that it enables the use of a single model to fit both early lung and early fecal data. For relatively insoluble materials this ratio [as predicted by the HRTM (ICRP 1994b)] increases almost linearly with AMAD and can be used to infer the "effective" AMAD (ICRP 2002;Doerfel et al 2006). It is termed the "effective" AMAD because it depends not only on the AMAD of the inhaled aerosol, but also on the subject's breathing pattern and airway morphology.…”

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

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ASSESSMENT OF INTAKES AND DOSES TO WORKERS FOLLOWED FOR 15 YEARS AFTER ACCIDENTAL INHALATION OF 60Co

Davis¹,

Marsh

Gerondal

et al. 2007

Health Physics

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Intakes and doses are assessed for seven workers who accidentally inhaled particles containing Co in the same incident. Comprehensive whole body data to 15 y, and some early urine and fecal data, are available for each individual. The biokinetic and dosimetric models currently recommended by ICRP have been used to assess these cases. It was not possible to obtain good fits to the data using the ICRP models with their default parameter values. However, good fits to all the measurement data were obtained by varying parameter values following a procedure similar to that recommended in recently developed guidelines for assessment of internal doses from monitoring data. It was found that retention in the lungs was much longer than predicted by the ICRP Human Respiratory Tract Model, and so for each case it was necessary to reduce the particle transport clearance of material from the deep lungs. This reduction in lung clearance rates, and the use of specific AMAD values, were the dominating factors in changing assessed doses from those calculated using ICRP default values.

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Section: Resultsmentioning

confidence: 99%

Section: Assessment Of Casementioning

confidence: 99%

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

Section: Step 3: Assign Realistic Measurement Uncertaintiesmentioning

confidence: 99%

See 3 more Smart Citations

ASSESSMENT OF INTAKES AND DOSES TO WORKERS FOLLOWED FOR 15 YEARS AFTER ACCIDENTAL INHALATION OF 60Co

Davis¹,

Marsh

Gerondal

et al. 2007

Health Physics

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Scattering factor evaluation and study of medical intervention following intake of 60Co

Gautam

Sharma

et al. 2010

J Radioanal Nucl Chem

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Modelling particle retention in the alveolar–interstitial region of the human lungs

Gregoratto¹,

Bailey²,

Marsh³

2010

J. Radiol. Prot.

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Better information is available now on long-term particle retention in the human lungs than there was in 1994, when the human respiratory tract model (HRTM) was adopted by the International Commission on Radiological Protection (ICRP). Three recent studies are especially useful because they provide such information for groups of people who inhaled very similar aerosols. For all three the HRTM significantly underestimates lung retention of insoluble material. The purpose of this work was to improve the modelling of long-term retention in the deep lung. A simple physiologically based model developed to predict lung and lymph node particle retention in coal miners was found to represent lung retention in these studies adequately. Instead of the three alveolar-interstitial (AI) compartments in the HRTM, it has an alveolar compartment which clears to the bronchial tree and to a second compartment, representing the interstitium, which clears only to lymph nodes. The main difference from the HRTM AI model is that a significant fraction of the AI deposit is sequestered in the interstitium. To obtain default parameter values for general use, the model was fitted to data from the three recent studies, and also the experimental data used in development of the HRTM to define particle transport from the AI region for the first year after intake. The result of the analysis is that about 40% of the AI deposit of insoluble particles is sequestered in the interstitium and the remaining fraction is cleared to the ciliated airways with a half-time of about 300 days. For some long-lived radionuclides in relatively insoluble form (type S), this increased retention increases the lung dose per unit intake by 50-100% compared to the HRTM value.

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IDEAS internal contamination database: a compilation of published internal contamination cases. A tool for the internal dosimetry community

Cited by 16 publications

References 0 publications

ASSESSMENT OF INTAKES AND DOSES TO WORKERS FOLLOWED FOR 15 YEARS AFTER ACCIDENTAL INHALATION OF 60Co

ASSESSMENT OF INTAKES AND DOSES TO WORKERS FOLLOWED FOR 15 YEARS AFTER ACCIDENTAL INHALATION OF 60Co

Scattering factor evaluation and study of medical intervention following intake of 60Co

Modelling particle retention in the alveolar–interstitial region of the human lungs

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