“…The use of these endectocides has become customary in the last few decades, and macrocyclic lactones, particularly ivermectin, are among the most widely sold drugs for the control of cattle parasites (Delgado et al, 2009;Neves et al, 2014). However, the continuous use of ivermectin has resulted in anthelmintic resistance, a widespread problem reported in the states of Minas Gerais (Rangel et al, 2005), Rio de Janeiro (Cardoso et al, 2008), Santa Catarina (Souza et al, 2008), Mato Grosso do Sul (Borges et al, 2013), São Paulo (Neves et al, 2014), Paraná (Holsback et al, 2015) and Rio Grande do Sul (Ramos et al, 2016).…”