Identification and Assessment of Therapeutic Phytoconstituents of Catharanthus roseus through GC-MS Analysis

Abstract

The leaves of Catharanthus roseus (L.) G. Don contain a large number of diverse secondary metabolites, making them comparably complex. The Catharanthus genus has received increased interest from scientists in recent years due to its extensive applications in several domains, including the pharmaceutical sector, where precise characterization of its characteristics is required. An effective inquiry technique is needed for chemo-profiling to identify the metabolites in plant samples. The main goal of this research is to provide supplementary data on the chemical composition of the leaves of twenty-five different accessions of C. roseus through the application of gas chromatography-mass spectrometry (GC-MS). The study’s findings reveal the existence of a vast number of phytochemicals, allowing for a comparison of the different accessions. Furthermore, a meticulous statistical analysis of this data using principal components analysis (PCA) and a heatmap, and hierarchical cluster analysis (HCA) may aid in providing more relevant information on C. roseus leaves for possible investigation of their metabolites in further scientific studies.

Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment

“…The GCMS analysis revealed that the CFEA contains numerous phytochemicals with beneficial biological effects. Some of these substances have been identified as having antimicrobial, antioxidant, and anti-inflammatory properties, including hexanoic acid, 2-ethyl anhydride, n-Hexadecanoic acid ( Thakur et al, 2018 ), glycerol 1,2-diacetate, Hexadecanoic acid ( El-Sayed et al, 2023 ), 1,2,3-Propanetriol, 1-acetate, benzofuran, 2,3-dihydro- ( Rani et al, 2023 ), 3-hydroxy-methyl ester ( Kumar et al, 2021 ), isopropyl hexacosyl ether, and 5-Hydroxymethyl-2-furaldehyde ( Fitriaturosidah et al, 2022 ). Additionally, phenol, 2,4-bis (1,1-dimethyl ethyl)-, has been found to have antifungal and biofilm-rupturing capabilities ( Sharaf, 2020 ), while D-Glucitol, 1,4-anhydro-, has antiophidic effects ( Singh et al, 2018 ).…”

Characterization of Langra Mango Peel Powder and Assessment of Its Prebiotic and Antioxidant Potential

“…Several studies have reported previously about the health-promoting properties of bioactive compounds such as polyphenols, favonoids, tannins, etc. [91][92][93][94]. In a recent study, mangiferin (C-glucosylxanthone), a natural compound from mango, has been found to have a chemoprotective mechanism against colonic aberrant crypt foci (ACF) in rats by lowering ACF values and less colon tissue penetration induced by azoxymethane [86].…”

Exploring the photochemical composition of indigenous Capparis Genus species in Iraq

“…Plant secondary metabolites may be qualitatively and quantitatively characterized using contemporary analytical methods such as spectrophotometry, high-performance liquid chromatography (HPLC), and gas-chromatography mass spectrometry (GC-MS) (Rani et al, 2023). While HPLC enables the simultaneous evaluation of antioxidant chemicals, spectrophotometry may be used to evaluate phenolics, flavonoids, saponins, and alkaloids.…”