Identification and association of polymorphisms in CAPN1 and CAPN3 candidate genes related to performance and meat quality traits in chickens

Felício, Andrezza Maria; Boschiero, Clarissa; Balieiro, J. C. C.; Ledur, Mônica Corrêa; Ferraz, José Bento Sterman; Filho, Tercio Michelan; Moura, Ana Silvia Alves Meira Tavares; Coutinho, Luiz Lehmann

doi:10.4238/2013.february.8.12

Cited by 29 publications

(22 citation statements)

References 21 publications

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“…PHKG1 causes high glycogen content and low meat quality in pig skeletal muscle [60]. CAPN3 is related to meat quality traits in chickens [61]. Reproduction traits: TYRO3 modulates female reproduction by influencing gonadotropin-releasing hormone [62].…”

Section: Resultsmentioning

confidence: 99%

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

et al. 2015

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BackgroundCommercial sheep raised for mutton grow faster than traditional Chinese sheep breeds. Here, we aimed to evaluate genetic selection among three different types of sheep breed: two well-known commercial mutton breeds and one indigenous Chinese breed.ResultsWe first combined locus-specific branch lengths and di statistical methods to detect candidate regions targeted by selection in the three different populations. The results showed that the genetic distances reached at least medium divergence for each pairwise combination. We found these two methods were highly correlated, and identified many growth-related candidate genes undergoing artificial selection. For production traits, APOBR and FTO are associated with body mass index. For meat traits, ALDOA, STK32B and FAM190A are related to marbling. For reproduction traits, CCNB2 and SLC8A3 affect oocyte development. We also found two well-known genes, GHR (which affects meat production and quality) and EDAR (associated with hair thickness) were associated with German mutton merino sheep. Furthermore, four genes (POL, RPL7, MSL1 and SHISA9) were associated with pre-weaning gain in our previous genome-wide association study.ConclusionsOur results indicated that combine locus-specific branch lengths and di statistical approaches can reduce the searching ranges for specific selection. And we got many credible candidate genes which not only confirm the results of previous reports, but also provide a suite of novel candidate genes in defined breeds to guide hybridization breeding.

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Section: Resultsmentioning

confidence: 99%

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

et al. 2015

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“…Cattle: Avilés et al, 2013;Casas et al, 2005;Costello et al, 2007or Chickens: Felício et al, 2013Shu et al, 2015;Zhang et al, 2008); however, it has not been previously described in Anser anser. Moreover, the genotype CC of c.2554T → C polymorphism of CAPN1 gene has been previously associated with an increase in live body weight (Felício et al, 2013) and the AA genotype of the c.3535G → A was associated with smaller WBSF values, lower water loss rates, and higher intramuscular force contents in chickens (Shu et al, 2015).…”

Section: Introductionmentioning

confidence: 92%

Association analysis of g.68G  → A SNP in CAPN1 gene with carcass and meat quality traits in goose raised in organic <i>dehesa</i>

Solé

Negro

Membrillo³

et al. 2016

Arch. Anim. Breed.

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Abstract. Meat quality is an important concern for the poultry industry. Domestic geese products obtained from free-range systems usually have rather tough meat, and it is necessary to select them to improve meat tenderness. The relation of the calpain 1 (CAPN1) gene with the post-mortem tenderness process of meat has been demonstrated in several species. Thus, the objective of the present study was to identify polymorphisms in this gene and to perform an association analysis between these polymorphisms and related economic traits in goose raised in the dehesa ecosystem. For the analysis, 50 geese of 3 different subpopulations (20 Embden Anser anser; 20 Toulouse Anser anser; 10 F1 cross) were studied. The experimental protocols were followed complying with principles of animal welfare. A novel SNP was found in the CAPN1 gene, g.68G → A. This polymorphism was statistically associated with different carcass and meat quality traits such as thigh muscle width (P = 0.020) and the b* 10-day meat colour parameter (P = 0.024) for the global goose population. The association of this gene with meat tenderness (Warner–Bratzler shear force) was confirmed in the case of female individuals of the Toulouse breed (P = 0.043). The results suggest the possibility of using molecular markers in CAPN1 gene as a potential tool for improving carcass and meat quality traits in goose breeding programmes.

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“…At the same time C4751T in CAPN1 has a significant association with shear force at 7, 14, and 21 days of postmortem [20]. In chickens, four SNPs (C2546T, G3535A, C7198A, and G9950A) of CAPN1 gene are associated with meat quality and tenderness traits according to Shu et al's and Felício et al's researches [21, 22]. Simultaneously, several polymorphisms of CAST have also been described and identified to be associated with carcass quality and production traits [23, 24].…”

Section: Introductionmentioning

confidence: 99%

Experimental Verification of CAPN1 and CAST Gene Polymorphisms in Different Generations of Da-Heng Broilers

Zhou

Xiong

Yang

et al. 2017

BioMed Research International

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The micromolar calcium activated neutral protease (CAPN1) and calpastatin (CAST) have been widely regarded as genes related to muscle growth and meat tenderness. The objective of this study was to verify the association of SNPs of CAPN1 and CAST genes with carcass and tenderness traits and search the possible change patterns of SNPs in CAPN1 and CAST genes in six generations of broiler breeding process for growth rate, efficiency, and reproduction, during the third generation and the ninth generation, respectively. We found that, for CAPN1, genetic effects between SNPs (G3535A, C7198A) and meat tenderness were similar in different generations, while SNP3 (G7324A) was a novel polymorphism and had significant association with carcass and tenderness traits (P < 0.05) in this study. Furthermore, there was significant association between SNP4 (G9950A) and carcass indexes instead of tenderness traits (P < 0.05) which was consistent in the two generations. Moreover, although SNP6 (G37868A) of CAST had no relevance to carcass traits or tenderness traits in the third generation, it showed significant association with LW and CW in the ninth generation (P < 0.05).

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Identification and association of polymorphisms in CAPN1 and CAPN3 candidate genes related to performance and meat quality traits in chickens

Cited by 29 publications

References 21 publications

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

Association analysis of g.68G  → A SNP in CAPN1 gene with carcass and meat quality traits in goose raised in organic <i>dehesa</i>

Experimental Verification of CAPN1 and CAST Gene Polymorphisms in Different Generations of Da-Heng Broilers

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Identification and association of polymorphisms in CAPN1 and CAPN3 candidate genes related to performance and meat quality traits in chickens

Cited by 29 publications

References 21 publications

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

Genome-Wide Specific Selection in Three Domestic Sheep Breeds

Association analysis of g.68G → A SNP in CAPN1 gene with carcass and meat quality traits in goose raised in organic &lt;i&gt;dehesa&lt;/i&gt;

Experimental Verification of CAPN1 and CAST Gene Polymorphisms in Different Generations of Da-Heng Broilers

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Association analysis of g.68G  → A SNP in CAPN1 gene with carcass and meat quality traits in goose raised in organic <i>dehesa</i>