Identification and benchmarking of Myokinasib-II as a highly selective and potent chemical probe for exploring MLCK1 inhibition
Gautam Kumar,
Prema Kumari Agarwala,
Aswin T. Srivatsav
et al.
Abstract:Deciphering functional relevance of every protein is crucial to developing a better (patho)physiological understanding of human biology. Discovery and use of quality chemical probes propel exciting developments for developing drugs in therapeutic areas with unmet clinical needs. Myosin Light Chain Kinase (MLCK) serves as a possible therapeutic target in a plethora of diseases, including inflammatory diseases, cancer etc. Recent years have seen substantial increase in interest in exploring MLCK biology. However… Show more
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