Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

Kozuka, Miyuki; Yamane, Toshimi; Nakano, Yoshihisa; Nakagaki, Takenori; Ohkubo, Iwao; Ariga, Hiroyoshi

doi:10.1016/j.bbrc.2015.08.031

Cited by 36 publications

(22 citation statements)

References 24 publications

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“…The anthocyanins cyanidin 3, 5-diglucoside isolated from the juice of aronia berries (Kozuka et al, 2015) and cyanidin 3-glucoside found in blackberry-blueberry wine blend (Fan et al 2013) have both been reported to have DPP-IV inhibitory activity (IC50 = 5.5 µM and 0.42 µM, respectively). Phytochemicals found in extracts from Greek oregano, rosemary, marjoram and Mexican oregano were also recently found to be able to inhibit the DPP-IV enzyme in a study by Bower, Hernandez, Berhow, & de Mejia (2015).…”

Section: Other Food Constituents With Dpp-iv Inhibitory Activitymentioning

confidence: 99%

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

Lacroix

Li‐Chan

2016

Trends in Food Science & Technology

150

107

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Background: Diabetes, which currently affects 1 in 11 adults, is considered one of the biggest worldwide health crises of the 21 st century. Over the last decade, synthetic inhibitors of the enzyme dipeptidyl-peptidase IV (DPP-IV) have emerged as an effective pharmaceutical approach for the management of type 2 diabetes. These molecules exert their beneficial effect by preventing the inactivation of gut-derived hormones that play a pivotal role in glycemic regulation. More recently, food components have been suggested as sources of DPP-IV inhibitors with the potential to help manage blood glucose levels.Scope and approach: This review examines the sources, production, molecular characteristics and modes of action of food-derived DPP-IV inhibitors. Insights into the needs for future research to validate their efficacy and to establish their application in the management of type 2 diabetes are also discussed. Key findings and conclusions:To date, hydrolysates of protein from a variety of food commodities, including both plant and animal sources, have been shown to be able to inhibit the activity of the DPP-IV enzyme. Moreover, a number of peptides, either isolated from these hydrolysates or synthetically produced, as well as non-protein-derived compounds such as polyphenols, have also been identified as DPP-IV inhibitors. These food-derived constituents present different degrees of potency and modes of action on the DPP-IV enzyme. While their effectiveness in humans is currently unknown, findings from in vitro and animal studies conducted to date warrant further research to evaluate their potential as functional food ingredients for glycemic regulation.

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Section: Other Food Constituents With Dpp-iv Inhibitory Activitymentioning

confidence: 99%

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

Lacroix

Li‐Chan

2016

Trends in Food Science & Technology

150

107

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“…Chlorogenic acid was found to be the most potent inhibitor of pancreatic α-amylase [16]. Other studies postulated that the antidiabetic effect of black chokeberry juice may be due to the cyaniding 3,5-diglucoside inhibition of DPP IV (dipeptidyl peptidase IV) [112]. It seems that in humans, black chokeberry juice can be an excellent natural alternative therapeutic strategy for the treatment of metabolic syndrome disorders, the dose varying from 100 ml to 300 ml per day, for at least 3 months [16].…”

Section: Anti-diabetic Effectmentioning

confidence: 99%

Cardioprotective Effects of Cultivated Black Chokeberries (Aroniaspp.): Traditional Uses, Phytochemistry and Therapeutic Effects

Buda¹,

Andor²,

Antal³

et al. 2021

Bioactive Compounds in Nutraceutical and Functional Food for Good Human Health

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Cardiovascular diseases represent the main cause of morbidity and mortality worldwide. Obesity, sedentary life style, diet, smoking and stress are the principal inducers of hypertension, endothelium dysfunction and insulin resistance in the developed countries. The latest in vitro and in vivo studies on different type of extracts obtained from black-fruited Aronia highlight its excellent cardioprotective actions for the prevention and treatment of cardiovascular and metabolic disorders. So, this chapter aims to bring an up-to-date regarding the antioxidant, antiinflammatory, anti-atherosclerotic, antiplatelet, blood pressure, glucose and lipid reduction properties of black-fruited Aronia, as a possible new therapeutic strategy for the primary and secondary prevention of cardiovascular pathologies.

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“…Kozuka et al [83] tested the juice of aronia berries (Aronia sp., Rosaceae) as DPP-4 inhibitors. Enzymatic activity was determined by fluorometry (excitation 380 nm and emission 440 nm), and DPP-4 inhibition was performed using L-proline 4-methyl-coumaryl-7-amide (Pro-MCA) as the substrate in Tris-HCl (pH 9.0).…”

Section: Potentiality Of Medicinal Plants As Incretin Modulatorsmentioning

confidence: 99%

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

et al. 2019

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Incretins are metabolic hormones released after a meal that increase insulin secretion from pancreatic β-cells. The two main incretins are the intestinal peptides glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. Both induce a decrease in glycemia, slow down the absorption of nutrients, and are inactivated by the enzyme dipeptidyl peptidase-4. Recently, incretin-based therapies have become a useful tool to treat diabetic patients, and different studies have focused on the identification of glucagon-like peptide-1 receptor agonists, including those of natural origin. This review focuses on the new findings of medicinal plants and natural products as possible active agents on the potentiation of incretin receptor signaling. Among these, soluble fiber from species of Plantago and guar gum show promising effects, iridoid derivatives are relevant activators of incretin receptors, and derivatives of cyanidin, especially diglycosylated ones, are an interesting source of dipeptidyl peptidase-4 inhibitors.

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Identification and characterization of a dipeptidyl peptidase IV inhibitor from aronia juice

Cited by 36 publications

References 24 publications

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation – Current knowledge and future research considerations

Cardioprotective Effects of Cultivated Black Chokeberries (Aroniaspp.): Traditional Uses, Phytochemistry and Therapeutic Effects

Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins

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