Identification and characterization of a brain-specific antigen enriched in neonatal brain. I. Developmental, regional distribution and molecular weight studies

Strong, Donna D.; Herschman, Harvey R.

doi:10.1016/0006-8993(78)90952-6

Brain Research

1978

DOI: 10.1016/0006-8993(78)90952-6

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Identification and characterization of a brain-specific antigen enriched in neonatal brain. I. Developmental, regional distribution and molecular weight studies

Donna D. Strong

Harvey R. Herschman

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Cited by 3 publications

References 24 publications

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Antigenic properties of the loosely bound subnuclear fraction of rat brain

Michetti

1980

Neurochem Res

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Antibodies against the loosely bound subnuclear fraction (0.35 M NaCl-extractable subnuclear fraction) of rat brain were raised in rabbits, and the distribution of the main antigenic determinants was followed among subcellular fractions of nervous tissue and among homologous nuclear preparations from different tissues. By immunofluorescence a localization restricted to the nucleus was observed, and by microcomplement fixation the antigens appeared to specifically enrich the fraction under examination, being poorly detectable in cytosol, nuclear sap, or deoxyribonucleoproteins of rat brain. No significant cross-reaction was observed by complement fixation with homologous preparations from muscle, liver, kidney, spleen, lung, or thymus of rat, whereas the 0.35 M NaCl-extracted subnuclear fraction from rat testis exhibited an immunoreactivity, although lower than that for brain proteins. After trypsin or ribonuclease treatment, the main antigenic determinants appeared to be protein in nature. The subnuclear fraction under examination, which is believed to be relevant to gene regulation, appears to contain protein antigens mainly concentrated in the nervous system.

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Antigenic properties of the loosely bound subnuclear fraction of rat brain

Michetti

1980

Neurochem Res

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Identification and characterization of a brain-specific antigen enriched in neonatal brain. II. Antigenic stability, species cross-reactivity and tumor cell association

Strong

Herschman

1980

Brain Research

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A novel soluble brain-specific protein (Sy-1)☆Identification and partial characterization

Gennarini¹,

Corsi²,

Pavia³

et al. 1983

Journal of Neuroimmunology

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Identification and characterization of a brain-specific antigen enriched in neonatal brain. I. Developmental, regional distribution and molecular weight studies

Cited by 3 publications

References 24 publications

Antigenic properties of the loosely bound subnuclear fraction of rat brain

Antigenic properties of the loosely bound subnuclear fraction of rat brain

Identification and characterization of a brain-specific antigen enriched in neonatal brain. II. Antigenic stability, species cross-reactivity and tumor cell association

A novel soluble brain-specific protein (Sy-1)☆Identification and partial characterization

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