2024
DOI: 10.1101/2024.04.27.591083
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Identification and characterization of alamandine-(1-5), a new component of the Renin-Angiotensin System with unique properties

Melissa Tainan Silva Dias,
Sthefanie Chaves de Almeida Gonçalves,
Filipe Alex da Silva
et al.

Abstract: The renin-angiotensin system (RAS) comprises a biochemical cascade that hydrolyzes angiotensinogen into several different bioactive peptides, which can activate different receptors promoting plenty of specific effects. The aim of this study was to evaluate the presence of the putative product of alamandine, the pentapeptide alamandine-(1-5) in the circulation and its biological activity. To accomplish this we have used mass spectrometry (MALDI/TOF/TOF, LC-MS/MS) and several methodologies including isolated blo… Show more

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