2023
DOI: 10.1155/2023/4615297
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Identification and Characterization of an Ageing-Associated 13-lncRNA Signature That Predicts Prognosis and Immunotherapy in Hepatocellular Carcinoma

Abstract: Background. In cancer pathology, cell senescence not only alters cell function but also reshapes the immune microenvironments in tumours. However, the association between cell senescence, tumour microenvironment, and disease progression of hepatocellular carcinoma (HCC) is yet to be fully understood. Therefore, the role of cell senescence-related genes and long noncoding RNAs (lncRNAs) in evaluating the clinical prognosis and immune cell infiltration (ICI) of HCC patients requires further investigation. Method… Show more

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“…However, the long-term accumulation of SnCs could lead to an enrichment of SASP in the TME, favoring the proliferation, malignancy, and resistance of non-SnCCs ( Figure 1C ). Indeed, recent studies suggest that patients with enrichment of senescent signatures have a worse prognosis for liver cancer ( Li and Xue, 2023 ; Zhang S et al, 2023 ), colorectal cancer ( Tan et al, 2023 ), glioma ( Yang et al, 2021 ), among others ( Zhang et al, 2022 ) with rare exceptions showing the opposite ( Zhou et al, 2022 ).…”
Section: Senescence In Cancer: Allies Turned Adversariesmentioning
confidence: 99%
“…However, the long-term accumulation of SnCs could lead to an enrichment of SASP in the TME, favoring the proliferation, malignancy, and resistance of non-SnCCs ( Figure 1C ). Indeed, recent studies suggest that patients with enrichment of senescent signatures have a worse prognosis for liver cancer ( Li and Xue, 2023 ; Zhang S et al, 2023 ), colorectal cancer ( Tan et al, 2023 ), glioma ( Yang et al, 2021 ), among others ( Zhang et al, 2022 ) with rare exceptions showing the opposite ( Zhou et al, 2022 ).…”
Section: Senescence In Cancer: Allies Turned Adversariesmentioning
confidence: 99%