2019
DOI: 10.1016/j.ijantimicag.2018.12.007
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Identification and characterization of novel isothiazolones with potent bactericidal activity against multi-drug resistant Acinetobacter baumannii clinical isolates

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Cited by 7 publications
(6 citation statements)
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“…Importantly, when the comparable compound MIT 1 was examined under the same conditions, significant cytotoxicity was evident at concentrations as low as 35 μM. This finding is in close agreement with a recent study that investigated the toxicity of MIT 1 and several other isothiazolone derivatives against human epithelial-like HepG2 cells . Xu and colleagues produced dose–response curves for several isothiazolones, including MIT 1 , and reported the IC 50 of MIT 1 as 73 μM, while other derivatives ranged from 32 to 58 μM .…”
Section: Results and Discussionsupporting
confidence: 83%
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“…Importantly, when the comparable compound MIT 1 was examined under the same conditions, significant cytotoxicity was evident at concentrations as low as 35 μM. This finding is in close agreement with a recent study that investigated the toxicity of MIT 1 and several other isothiazolone derivatives against human epithelial-like HepG2 cells . Xu and colleagues produced dose–response curves for several isothiazolones, including MIT 1 , and reported the IC 50 of MIT 1 as 73 μM, while other derivatives ranged from 32 to 58 μM .…”
Section: Results and Discussionsupporting
confidence: 83%
“…This finding is in close agreement with a recent study that investigated the toxicity of MIT 1 and several other isothiazolone derivatives against human epithelial-like HepG2 cells. 55 Xu and colleagues produced dose−response curves for several isothiazolones, including MIT 1, and reported the IC 50 of MIT 1 as 73 μM, while other derivatives ranged from 32 to 58 μM. 55 Taken together, these results strongly suggest that the addition of a nitroxide to the isothiazolone core can significantly reduce its human cytotoxicity.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
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“…The discrepancy between broth micro-and macrodilution assays can be up to 0.3 fold for fluconazole in one study (laboratory) using the same microbial strain. 134 However, Table 1. 4 indicates that the discrepancy between broth micro-and macrodilution assays between studies for the same ITC (e.g AITC) and microbial species (e.g.…”
Section: Occurrence Of Gsls and Itcsmentioning
confidence: 99%
“…[127][128][129][130][131] ITZs are another class of electrophilic antimicrobials (Figure 6.4B), which receive much research and industrial interest. [131][132][133][134][135][136] ITZs have AM1_electrophilicity values in the range of shown in an in vitro study. 114 Furthermore, ITCs might elevate ROS levels in Bacillus by reacting with low-molecular-weight (LMW) thiol molecules, e.g.…”
Section: Hints For the Mode Of Actionmentioning
confidence: 99%