Identification and characterization of photodegradation products of metoprolol in the presence of natural fulvic acid by HPLC-UV-MSn

Filipe, Olga M.S.; Mota, Nuno; Santos, Sónia A.O.; Domingues, Rosário M.; Silvestre, Armando J. D.; Neves, Maria G. P. M. S.; Simões, Mário M. Q.; Santos, Eduarda B.H.

doi:10.1016/j.jhazmat.2016.05.072

Cited by 24 publications

(9 citation statements)

References 41 publications

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“…It is well known that ROS have an extremely short lifetime due to their very unstable electronic configuration and their diffusion range is consequently small and dependent on the environment type [21]. The fact that the WW used as WW medium have a high quantity of organic matter could allow for the appearance of different microenvironments with different 1 O 2 diffusion rates and lifetimes [38,39]; additionally, the presence of compounds able to generate ROS [41] can affect the rate of bacterial inactivation and consequently be responsible for the differences observed in the inactivation rate between the tests performed in PBS and WW medium. Further studies using WW with different content of organic matter are needed in order to test this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Bartolomeu

Reis

Fontes

et al. 2017

Water

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Wastewater (WW) from urban and industrial activities is often contaminated with microorganisms and chemical pollutants. To reduce the concentration of microorganisms in WW to levels comparable to those found in natural waters, the sewage effluent is usually subjected to disinfection with chlorine, ozone, or ultraviolet light, which may lead to the formation of toxic products and contribute to the selection of resistant genes. Moreover, the changing patterns of infectious diseases and the emerging of multidrug resistant microbial strains entail the development of new technologies for WW decontamination. Microbial photodynamic inactivation (PDI) with photosensitizers, oxygen, and visible light has demonstrated to be effective in the inactivation of microorganisms via photogeneration of reactive oxygen species able to induce microbial damage at the external structures level. The promising results of PDI suggest that this principle can be applied to WW treatment to inactivate microorganisms but also to photodegrade chemical pollutants. The aim of this study was to assess the applicability of PDI for the microbial and chemical decontamination of secondarily treated WW. To evaluate the efficiency of bacterial inactivation in WW, experiments were done in both phosphate buffer saline (PBS) and filtered WW with the bioluminescent Escherichia coli, using small and large volumes of WW. The potential of PDI to inactivate the native bacteria (E. coli and Enterococcus) present in WW was tested and assays without the adding of bacteria to the WW were performed. It was also tested if the same PDI protocol was able to induce phototransformation of phenol. The cationic porphyrin 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin tetra-iodide (Tetra-Py + -Me) was shown to be effective against both bacterial groups representing both Gram-negative and Gram-positive bacteria used as microbiological parameters to instigate water quality and even showing the power to photooxidate organic compounds. As the photosensitizer when immobilized on solid matrixes can be easily removed, recovered, and reused, an effective, less-expensive, easy-applicable, and environmentally friendly technology can be applied to treat WW, inactivating microorganisms and degrading chemical contaminants at the same time.

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Section: Discussionmentioning

confidence: 99%

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Bartolomeu

Reis

Fontes

et al. 2017

Water

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“…Metoprolol is subject to indirect photodegradation in the presence of natural organic matter. 24 It has also been shown to degrade rapidly at warm temperatures (19.7 C) under oxic/penoxic to suboxic conditions in sediment. 25 3.6.2.…”

Section: Comparison Of Persistence In the Eld And The Laboratorymentioning

confidence: 99%

Comparing non-targeted chemical persistence assessed using an unspiked OECD 309 test to field measurements

McLachlan

2020

Environ. Sci.: Processes Impacts

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“…There are various reports showing the photodegradation of several medicines, such as non-steroidal anti-inflammatory drugs (NSAIDs), calcium channel blockers, antiepilepsy drugs, antibiotic drugs and beta blockers [1][2][3][4][5][6][7]. These reports suggest that it is important to consider the photostability of the medicine in the case that it might be photo-irradiated.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Photodegradation of Crushed- and Suspended Pranoprofen Tablets

et al. 2021

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Herein, we evaluate the photostability of pranoprofen (PP) tablets (NIFLAN ® 75 mg), its powdered and suspended forms. PP is a member of the 2-arylpropionic acid family of NSAIDs. The content of the active compound was monitored by high-performance liquid chromatography (HPLC) using an ODS column with ultraviolet light (UV) detector. The residual amount of PP in the powder was 86.5%, which was comparable to that of in the suspension (85.4%) after UV irradiation for 24 hr. Further UV irradiation (total irradiation time of 7 days) resulted in the significant photodegradation of PP in the suspension (residual amount: 55.5%), compared to that of 1 day irradiation. However, the residual amount of PP in the powder was 78.6% after 7 days irradiation as the same to that of 1 day irradiation. To identify the chemical structure of five photoproducts generated from the UV-irradiated PP dosage forms, electrospray ionization liquid chromatography mass spectrometry (ESI-LC/MS/MS) analysis was performed. From these results, photodegradation of PP was observed through changing dosage forms. This is the first report evaluating the generation of PP photoproducts induced by the UV irradiation in the formulation.

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Identification and characterization of photodegradation products of metoprolol in the presence of natural fulvic acid by HPLC-UV-MSn

Cited by 24 publications

References 41 publications

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Photodynamic Action against Wastewater Microorganisms and Chemical Pollutants: An Effective Approach with Low Environmental Impact

Comparing non-targeted chemical persistence assessed using an unspiked OECD 309 test to field measurements

Evaluation of the Photodegradation of Crushed- and Suspended Pranoprofen Tablets

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