2012
DOI: 10.1194/jlr.m020313
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Identification and characterization of two bile acid coenzyme A transferases from Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium

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Cited by 122 publications
(122 citation statements)
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References 27 publications
(26 reference statements)
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“…4). 63,72 The function of the baiJ gene is unknown, though it is predicted to encode a flavoprotein possibly involved in C-C double bond oxidation/reduction. However, it is doubtful it is involved in the "reductive" The genes encoding enzymes carrying out bile acid metabolism in gut bacteria capable of producing secondary bile acids.…”
Section: Bile Acid 7a/7b-dehydroxylation By Intestinal Bacteriamentioning
confidence: 99%
See 1 more Smart Citation
“…4). 63,72 The function of the baiJ gene is unknown, though it is predicted to encode a flavoprotein possibly involved in C-C double bond oxidation/reduction. However, it is doubtful it is involved in the "reductive" The genes encoding enzymes carrying out bile acid metabolism in gut bacteria capable of producing secondary bile acids.…”
Section: Bile Acid 7a/7b-dehydroxylation By Intestinal Bacteriamentioning
confidence: 99%
“…Rodent, 61 but not human bile acid 7a-dehydroxylating bacteria are capable of 7a-dehydroxylating muricholic acids (6a, 7b-hydroxy; 6b, 7b-hydroxy). 62 Characterization of the genetics and molecular biology of bile acid 7a/b-dehydroxylation has been performed mainly in strains of Clostridium scindens, 8,63 particularly C. scindens VPI 12708 (formerly Eubacterium sp. strain VPI 12708).…”
Section: Bile Acid 7a/7b-dehydroxylation By Intestinal Bacteriamentioning
confidence: 99%
“…Interestingly, a phylogenetic analysis of the bacterial OTUs revealed that Clostridium cluster XI is composed of a single bacterial taxon (OUT-1105) close to the DCA-producing strain Clostridium sordellii (35). Thus, although other bacteria may also participate, the simplest explanation for our data is that OUT-1105 contributes to an increase in the DCA level, at least to some extent, in obese mice.…”
Section: An Obesity-induced Gut Microbial Metabolite Promotes Hepatocmentioning
confidence: 60%
“…At the same time, microbial inhabitants of the ileum and colon initiate another molecular modification: 7-dehydroxylation. The removal of the C-7 hydroxyl group, a highly efficient process performed by resident genera, including Clostridium, converts cholate to deoxycholate, a secondary bile acid (24,25). These secondary bile acids are also recovered via enterohepatic circulation and returned to the gallbladder to be released in the duodenum upon gallbladder contraction.…”
mentioning
confidence: 99%