Identification and characterization of β-sitosterol target proteins

Lomenick, Brett; Shi, Heping; Huang, Jing; Chen, Chuo

doi:10.1016/j.bmcl.2015.03.007

Cited by 28 publications

(17 citation statements)

References 37 publications

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“…Thereby, materials with moisturizing and anti-wrinkling activities are potential candidates to anti-aging ingredients in skincare formulations. Sito generally exists in human diet as well as many medicinal plants and possesses anti-cancer, antiinflammatory and analgesic activities (Lomenick et al 2015, Villaseñor et al 2002. Verm is a main characteristic component in T. vermicularis with physiological activities of anti-inflammatory and antipyretic (guo et al 2011, Crawford 2015).…”

Section: Discussionmentioning

confidence: 99%

The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro

Haiyuan

Shen

Liú³

et al. 2019

An. Acad. Bras. Ciênc.

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Aged skin, featured with dryness and wrinkles, has received mounting attention due to its adverse influences on beauty. β-Sitosterol and vermicularin are two common active ingredients of Thamnolia vermicularis (Sw.) Ach., a traditional Chinese medicine, of which the anti-aging effect has been discovered. Their protective performance against skin aging was assayed by co-culturing with skin cells in this work. Results showed that β-sitosterol promoted the biosynthesis of hyaluronic acid by increasing the expression of hyaluronic acid synthases in fibroblasts and enhanced the expression of skin barrier functional proteins including aquaporin 3, loricrin, filaggrin and involucrin in keratinocytes, which conduced to the moisture retention within skin. Moreover, vermicularin might function as an anti-wrinkle agent by preventing the loss of collagen type I. Specifically, vermicularin reduced the amount of reactive oxygen species within hydrogen-peroxide-induced fibroblasts; together with suppressing the activation of mitogen-activated protein kinases, it could inhibit the production of matrix metalloproteinases-1. The present research will contribute to the development of the compounds as anti-aging ingredients for future applications in cosmetic formulations and functional food as well as promote further studies of raw materials containing alike compounds.

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Section: Discussionmentioning

confidence: 99%

The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro

Haiyuan

Shen

Liú³

et al. 2019

An. Acad. Bras. Ciênc.

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“…It also has anti-inflammatory, analgesic properties, and reducing the symptoms of benign prostatic hyperplasia in various animal models. [17] The HPTLC, as the advanced analytical technique, has the benefit of quick analysis as numerous samples can be run concurrently and ensuing quick comparison of phytochemical profiles. [18,19] This analytical technique used for the concurrent analysis of different constituents present in the A. indica plant material.…”

Section: Discussionmentioning

confidence: 99%

Development of bioanalytical standardization parameters of Alocasia indica tuber by HPTLC technique

Aneshwari¹,

Sahu²,

Vyas³

et al. 2020

Int. J. Pharm. Sci. Drug Res.

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Alocasia indica is perennial herb growing widely and used as traditional medicine in India, China and Bangladesh. The divine herb has potent medicinal values for the treatment of different type of illnesses. The HPTLC techniques were used to separate active components from ethanolic extract of tuber part of A. indica. This examination was intended to designed a HPTLC fingerprint profile of crude extract of the plant in ethanol. A HPTLC method for the isolation of various active constituents in A. indica ethanolic extract have been developed and solvent system for quercetin the mobile phase used was toluene: ethyl acetate: formic acid (5:2:1) and for analysis of β-sitosterol the mobile phase used was chloroform: ethyl acetate: formic acid (6:4:1) . In the present investigation, HPTLC fingerprint of extract of dried tuber part of A. indica have been performed and the results demonstrated that important information for standardization. The HPTLC system for routine quality control of present species can be used for ethanolic extract and serve in qualitative, quantitative and was appropriate for standardization of the plant.

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“…Also, anti-infective studies of Sassafras albidum and its bioactivity guided fractionation reported a sterol and fatty alcohol, 162 and 163 respectively [36] as promising antileishmanial compounds. 162 which differs from cholesterol at C24 position is believed to kill the parasite via an apoptosis mechanism involving DNA fragmentation, inhibition of inflammation cytokines and the activation of caspases [148,149]. Evaluating the suicidal action of active isolates from Pentalinon andrieuxii, 181 induced changes in immune responses particularly via necrosis and apoptosis characterized by increase in IL2 and IFN-γ which insinuates the control of pro-inflammatory cytokines by anti-inflammatory counterparts [150].…”

Section: Steroidsmentioning

confidence: 99%

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

Sakyi

Amewu

Devine

et al. 2021

Nat. Prod. Bioprospect.

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Despite advancements in the areas of omics and chemoinformatics, potent novel biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The socioeconomic burden of leishmaniasis remains alarming in endemic regions. Currently, reports from existing endemic areas such as Nepal, Iran, Brazil, India, Sudan and Afghanistan, as well as newly affected countries such as Peru, Bolivia and Somalia indicate concerns of chemoresistance to the classical antimonial treatment. As a result, effective antileishmanial agents which are safe and affordable are urgently needed. Natural products from both flora and fauna have contributed immensely to chemotherapeutics and serve as vital sources of new chemical agents. This review focuses on a systematic cross-sectional view of all characterized anti-leishmanial compounds from natural sources over the last decade. Furthermore, IC50/EC50, cytotoxicity and suggested mechanisms of action of some of these natural products are provided. The natural product classification includes alkaloids, terpenes, terpenoids, and phenolics. The plethora of reported mechanisms involve calcium channel inhibition, immunomodulation and apoptosis. Making available enriched data pertaining to bioactivity and mechanisms of natural products complement current efforts geared towards unraveling potent leishmanicides of therapeutic relevance. Graphic Abstract

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Identification and characterization of β-sitosterol target proteins

Cited by 28 publications

References 37 publications

The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro

The protective effects of β-sitosterol and vermicularin from Thamnolia vermicularis (Sw.) Ach. against skin aging in vitro

Development of bioanalytical standardization parameters of Alocasia indica tuber by HPTLC technique

The Search for Putative Hits in Combating Leishmaniasis: The Contributions of Natural Products Over the Last Decade

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