Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: 
            Brief Communication
            2

Pauly, John L.; Schuller, Mark G.; Zelcer, Alan A.; Kirss, Tiina; Gore, S.; Germain, Margit J.

doi:10.1093/jnci/58.6.1587

Cited by 73 publications

(41 citation statements)

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“…High levels of PD-ECGF/TP are observed in a variety of human tumours (Kono et al, 1984;Vertongen et al, 1984;Yoshimura et al, 1990), and a higher level of serum PD-ECGF/TP is observed in cancer patients compared with healthy control patients (Pauly et al, 1977). Apart from neoplastic disorders, angiogenesis plays a critical role in the pathogenesis of a number of benign diseases, such as osteo-and rheumatoid arthritis (Brown et al, 1988;Koch et al, 1994).…”

Section: Pd-ecgf/tp Correlation With Other Tumour Variablesmentioning

confidence: 99%

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

Koukourakis

Giatromanolaki²,

O’Byrne³

et al. 1997

Br J Cancer

119

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Summary Angiogenesis is a recently described prognostic factor in non-small-cell lung cancer. Platelet-derived endothelial cell growth factor (PD-ECGF), shown to be the enzyme thymidine phosphorylase (TP), induces angiogenesis in vitro and in vivo. High intracellular levels of the enzyme are associated with increased chemosensitivity to pyrimidine antimetabolites. PD-ECGF/TP expression was evaluated immunohistochemically in surgically resected specimens from 107 patients with operable non-small-cell lung cancer using the P-GF.44C monoclonal antibody. High expression of PD-ECGF/TP was found in 25% of cases and was associated with high vascular grade (P = 0.01). Fourteen of 32 (44%) high vascular grade tumours showed a positive reactivity for PD-ECGF/TP vs 13/75 (17%) of low/medium vascular grade. Positive expression was observed more frequently in T2-staged cases than in Ti (P = 0.04). While overall survival was not affected (P = 0.09), subset analysis revealed that node-negative patients with positive PD-ECGF/TP expression had a worse prognosis (P = 0.04). The results suggest that PD-ECGF/TP may be an important molecule involved in angiogenesis in non-small-cell lung cancer. Up-regulation of the enzyme defines a more aggressive tumour phenotype in patients with node-negative disease. Assessment of vascular grade and PD-ECGF/TP expression should be taken into account in the design of randomized trials assessing the role of adjuvant chemotherapy in nonsmall-cell lung cancer.

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Section: Pd-ecgf/tp Correlation With Other Tumour Variablesmentioning

confidence: 99%

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

Koukourakis

Giatromanolaki²,

O’Byrne³

et al. 1997

Br J Cancer

119

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“…Elevated thymidine phosphorylase enzyme activity has been reported in breast tumours (Patterson et al, 1995) and has also been detected in plasma of tumour-bearing animals and humans (Pauly et al, 1977(Pauly et al, , 1978. It is not clear whether this is due to its release from the tumour itself or production and release by host cells and tissues in response to tumour growth/proliferation.…”

Section: In Vivo Localization Of Pd-ecgf/dthdpasementioning

confidence: 99%

Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy

Griffiths

Stratford²

1997

Br J Cancer

103

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Summary Angiogenesis plays an important role in the growth and metastasis of solid tumours. Platelet-derived endothelial cell growth factor (PD-ECGF) is known to be chemotactic for endothelial cells in vitro and angiogenic in vivo. It is also known as gliostatin, a factor promoting neuronal survival, and thymidine phosphorylase (dThdPase), which catalyses the reversible phosphorylation of thymidine to thymine and 2-deoxyribose-1-phosphate. This enzymatic activity is critical for angiogenic activity. PD-ECGF protein is highly expressed in tumours compared with most normal tissues and has been correlated with tumour growth, invasion and metastasis in clinical studies. In addition, dThdPase activity (by inference PD-ECGF) has been found to be a major determinant of the toxicity of 5-fluorouracil and its prodrugs, which are extensively studied clinically as anti-cancer agents. This review attempts to summarize recent gains in understanding the nature, location and action of PD-ECGF and its specific relevance to tumour biology.

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“…7 TP reactivity reportedly is increased considerably in tumor tissues relative to neighboring normal tissues in a variety of malignancies. 12,13 In human malignancies of various organs, different patterns of stromal and tumor cell-TP expression have been observed. 14 -24 In colorectal carcinoma, 14,15 , gastric carcinoma, 17 and breast carcinoma, 18,19 intensive TP expression has been observed in intratumoral macrophages.…”

mentioning

confidence: 99%

Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma

Kojima

Shijubo

Abe

2002

Cancer

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Sleeping giants: As a mimic of cell agglomeration to form tissues, a novel vesicle aggregation process with the characteristic advantages of being highly efficient, light‐responsive, reversible, large‐scale, and stable is reported. Giant hyperbranched polymer vesicles (5–10 μm) are used as the building blocks (see scheme), and the vesicle aggregates can assemble and disassemble with alternating UV and Vis irradiation.

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Identification and Comparative Analysis of Thymidine Phosphorylase in the Plasma of Healthy Subjects and Cancer Patients: Brief Communication 2

Cited by 73 publications

References 0 publications

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancer

Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy

Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma

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