Identification and concentration of soy phytoestrogens in commercial dog foods

Cerundolo, Rosario; Court, Michael H.; Qin, Hao; Michel, Kathryn E.

doi:10.2460/ajvr.2004.65.592

Cited by 21 publications

(26 citation statements)

References 31 publications

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“…Plant material is used to extend the shelf life of dry diets and provides a necessary source of carbohydrate for the expansion and cooking processes of dry diets (Zoran 2002). Previous evaluations of the isofl avone content of companion animal diets have found a signifi cant correlation between soy and isofl avone content (Court and Freeman 2002;Cerundolo et al 2004). Our fi ndings also demonstrated a signifi cant relationship between the total content of isofl avone and the inclusion of soy.…”

Section: Discussionsupporting

confidence: 61%

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The isoflavone content of commercially-available feline diets in New Zealand

Bell¹,

Rutherfurd²,

Hendriks

2006

New Zealand Veterinary Journal

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Section: Discussionsupporting

confidence: 61%

“…Over 75% of the diets evaluated were found to contain at least one of the four isofl avones investigated, which is considerably higher than the 46% of feline diets (Court and Freeman 2002) or the 57% of canine diets (Cerundolo et al 2004) reported for North America.…”

Section: Discussionmentioning

confidence: 73%

The isoflavone content of commercially-available feline diets in New Zealand

Bell¹,

Rutherfurd²,

Hendriks

2006

New Zealand Veterinary Journal

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“…Diets of other animal species contain large amounts of PE such as those detected in commercial chow of cats (Setchell et al, 1987 andFreeman, 2002), dogs (Cerundolo et al, 2004) and rodents (Thigpen et al, 1999, Brown and Setchell, 2001and Degen et al, 2002 with the protein source being soy meal. These findings indicate that all investigators should be vigilant to the PE composition of laboratory animal diets because these agents might have a direct effect on the outcome of bioassays designed to detect developmental toxicity or carcinogenicity (Casanova et al, 1999, Thigpen et al, 1999and Brown and Setchell, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic exposure to soy meal containing diet or soy derived isoflavones supplement on semen production and reproductive system of male rabbits

Cardoso¹,

Báo²

2007

Animal Reproduction Science

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Effects of chronic exposure to soy meal containing diet or soy derived isoflavones supplement on semen production and reproductive system of male rabbits Julio Roquete Cardoso Sonia Nair Báo AbstractSoy and derivative diets deliver large doses of isoflavones to human and animals throughout their lifespan, including gestation. Epidemiologic and experimental data suggest that the consumption of soybean containing foods may protect against cardiovascular disease and decrease breast, prostate and endometrial cancer risk. Based on animal and in vitro studies, however, concerns have been raised that consumption of isoflavones may cause potential adverse effects on the reproductive tract and behavior. The aim of this study was to investigate the effects of chronic consumption of a soy meal containing diet or soy isoflavones supplement on the morphology of reproductive organs, semen quality, age that males reached puberty, and sexual behavior of male rabbits. With this purpose, 16 female rabbits were randomly assigned to receive: (1) a soy-and alfafa-free diet; (2) a soy-and alfafa-free diet supplemented with 5 mg/kg body wt./day of soy isoflavones; (3) a soy-and alfafa-free diet supplemented with 20 mg/kg body wt./day of soy isoflavones; (4) a diet containing 18% of soy meal, throughout the gestation and lactation. After weaning, male offspring received the same diet, which was given to the respective mother. The age that males reached puberty, semen characteristics and sexual behavior were evaluated in these animals. At 33 weeks of age, the reproductive organs were submitted to histological evaluation. Rabbits, which received large amounts of isoflavones (20 mg/kg body wt./day) had a lesser food intake, body weight and semen volume. Spermatogenesis, morphology of male genital organs and sexual behavior did not differ significantly from the control group. We conclude that chronic dietary treatment with soy based diet or soy isoflavones have no adverse effects on the observed reproductive patterns of male rabbits.

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“…Nevertheless, both bone meal and/or soybean meal are common ingredients in commercial dog chows. (65) Normal bone maintenance in dogs has been shown time and again in diets containing 0.5% Ca. (66) Bone meal and other various by-products can provide an overabundance of Ca, and soybean meal provides unnecessarily high concentrations of phytoestrogens (65) that can influence bone metabolism.…”

Section: Dogsmentioning

confidence: 99%

“…(65) Normal bone maintenance in dogs has been shown time and again in diets containing 0.5% Ca. (66) Bone meal and other various by-products can provide an overabundance of Ca, and soybean meal provides unnecessarily high concentrations of phytoestrogens (65) that can influence bone metabolism. (67) One only has to peruse the literature related to OVX and OHX dogs that report dietary mineral contents to realize Ca concentrations are routinely excessive (>1% (26,27,(44)(45)(46)(47)(48)59,63) ) in those studies not deliberately restricting or controlling Ca intakes.…”

Section: Dogsmentioning

confidence: 99%

Review of Nonprimate, Large Animal Models for Osteoporosis Research

Reinwald

Burr

2008

Journal of Bone and Mineral Research

134

108

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Large animal models are required for preclinical prevention and intervention studies related to osteoporosis research. The challenging aspect of this requirement is that no single animal model exactly mimics the progression of this human-specific chronic condition. There are pros and cons associated with the skeletal, hormonal, and metabolic conditions of each species that influence their relevance and applicability to human physiology. Of all larger mammalian species, nonhuman primates (NHPs) are preeminent in terms of replicating important aspects of human physiology. However, NHPs are very expensive, putting them out of reach of the vast majority of researchers. Practical, cost-effective alternatives to NHPs are sought after among ungulate (porcine, caprine, and ovine) and canine species that are the focus of this review. The overriding caveat to using large lower-order species is to take the time in advance to understand and appreciate the limitations and strengths of each animal model. Under these circumstances, experiments can be strategically designed to optimize the potential of an animal to develop the cardinal features of postmenopausal bone loss and/or yield information of relevance to treatment.

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Identification and concentration of soy phytoestrogens in commercial dog foods

Cited by 21 publications

References 31 publications

The isoflavone content of commercially-available feline diets in New Zealand

The isoflavone content of commercially-available feline diets in New Zealand

Effects of chronic exposure to soy meal containing diet or soy derived isoflavones supplement on semen production and reproductive system of male rabbits

Review of Nonprimate, Large Animal Models for Osteoporosis Research

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