Identification and determination of mainstream and sidestream smoke components in different brands and types of cigarettes by means of solid-phase microextraction–gas chromatography–mass spectrometry

Pieraccini, Giuseppe; Furlanetto, Sandra; Orlandini, Serena; Bartolucci, Gianluca; Giannini, Iacopo; Pinzauti, S.; Moneti, Gloriano

doi:10.1016/j.chroma.2007.12.029

Cited by 75 publications

(39 citation statements)

References 41 publications

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“…3 Gas chromatography (GC) is one of the most promising methods for the analysis of smoking-related VOCs, because of their selectivity, and gas chromatography-mass spectrometry (GC-MS) has been realized as a powerful tool for a sensitive determination of typical VOCs and semi-volatile organic compounds (SVOCs) in tobacco smoke. 4,5 However, a sample preconcentration process should still be needed for accurate and precise determination of these VOCs. Especially, the VOCs concentration related to third-hand smoking could be at a quite low level, and therefore an effective sample preparation process and subsequent separation/determination methods are needed.…”

Section: Introductionmentioning

confidence: 99%

Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking

et al. 2010

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“…The response surface with a second-order quadratic model was used to correlate between responses and changeable parameters. For the optimisation of experimental design, a set of six different classes of organic compounds (styrene, pyridine, decane, ethylbenzene, oxylene and naphthalene) were selected amongst all compounds present in MTS-VP samples collected from the reference material [1,32]. Their selection was based on their significance in tobacco smoke and to cover a large range of volatilities and polarities.…”

Section: Experimental Design Approach For Direct Td Trappingmentioning

confidence: 99%

Thermal desorption comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry for vapour phase mainstream tobacco smoke analysis

Savareear

Brokl

Wright

et al. 2017

Journal of Chromatography A

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a b s t r a c tA thermal desorption comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (TD-GC × GC-TOFMS) method has been developed for the analysis of mainstream tobacco smoke (MTS) vapour phase (VP). The selection process of the sample introduction approach involved comparing the results obtained from three different approaches: a) use of gas sampling bag followed by SPME (Tedlar ® -SPME), b) gas sampling bag followed by TD (Tedlar ® -TD), and c) sampling directly on TD sorbents (Direct-TD). Six different SPME fibers and six different TD sorbent beds were evaluated for the extraction capacities in terms of total number of peaks and related intensities or peak areas. The best results were obtained for the Direct-TD approach using Tenax TA/Carbograph1TD/Carboxen1003 sorbent tubes. The optimisation of TD tube desorption parameters was carried out using a face-centered central composite experimental design and resulted in the use of the Tenax TA/Carbograph 1TD/Carboxen 1003 sorbent with a 7.5 min desorption time, a 60 mL/min tube desorption flow, and a 250• C tube desorption temperature. The optimised method was applied to the separation of MTS-VP constituents, with 665 analytes detected. The method precision ranged from 1% to 15% for over 99% of identified peak areas and from 0% to 3% and 0% to 1% for both first ( 1 t R ) and second ( 2 t R ) dimension retention times, respectively. The method was applied to the analyses of two cigarette types differing in their filter construction. Principal component analysis (PCA) allowed a clear differentiation of the studied cigarette types (PC1 describing 94% of the explained variance). Supervised Fisher ratio analysis permitted the identification of compounds responsible for the chemical differences between the two sample types. A set of 91 most relevant compounds was selected by applying a Fisher ratio cut-off approach and most of them were selectively removed by one of the cigarette filter types.

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“…The presence of these toxic compounds in cigarette smoke has been recognized as an important issue for development of rapid, sensitive and accurate quantitative methods for the analysis of these compounds. There are few available methods for determination and quantification of PY, 3-methylpyridine (MPY), 2,4-lutidine (lU) and quinoline (QUI) such as electrostatic precipitation [5], gas chromatography (gC) [6,7] and gas chromatography-mass spectrometry (gC-MS) [8][9][10][11][12]. But some extraction or sample preparation steps are necessary for preconcentration and sample cleanup to improve detection limits and reduce matrix interferences.…”

Section: Introductionmentioning

confidence: 99%

Electrical field-stimulated liquid-phase microextraction for trace analysis of pyridine and its derivatives in cigarette extract

et al. 2014

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Identification and determination of mainstream and sidestream smoke components in different brands and types of cigarettes by means of solid-phase microextraction–gas chromatography–mass spectrometry

Cited by 75 publications

References 41 publications

Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking

Determination of Volatile Organic Compounds for a Systematic Evaluation of Third-Hand Smoking

Thermal desorption comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry for vapour phase mainstream tobacco smoke analysis

Electrical field-stimulated liquid-phase microextraction for trace analysis of pyridine and its derivatives in cigarette extract

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