Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population

Abstract

To summarize and assess the credibility and strength of non-genetic factors and genetic variation on gastric cancer risk, we performed a field synopsis and meta-analysis to identify the risk of gastric cancer in Chinese population. Cumulative evidence was graded according to the Venice criteria, and attributable risk percentage ( ARP ) and population attributable risk percentage ( PARP ) were used to evaluate the epidemiological effect. A total of 956 studies included non-genetic (404 studies) and genetic factors (552 studies) were quantified, and data on 1161 single nucleotide polymorphisms (SNPs) were available. We identified 14 non-genetic factors were significantly associated with gastric cancer risk. For the analysis of time trends, H. pylori infection rate in gastric cancer and population showed a downward trend. Meanwhile 22 variants were identified significantly associated with gastric cancer: 3 ( PLCE1 rs2274223, PSCA rs2976392, MUC1 rs4072037) were high and 19 SNPs were intermediate level of summary evidence, respectively. For non-genetic factors, the top three for ARP were 54.75% (pickled food), 65.87% (stomach disease), and 49.75% (smoked and frying). For PARP were 34.22% (pickled food), 34.24% (edible hot food) and 23.66%( H. pylori infection). On the basis of ARP and PARP associated with SNPs of gastric cancer, the top three for ARP were 53.91% ( NAT2 , rs1799929),53.05% ( NAT2 phenotype), and 42.85% ( IL-10 , rs1800896). For PARP (Chinese Han in Beijing) were 36.96% ( VDR , rs731236), 25.58% ( TGFBR2 , rs3773651) and 20.56% ( MUC1 , rs4072037). Our study identified non-genetic risk factors and high-quality biomarkers of gastric cancer susceptibility and their contribution to gastric cancer.

Association of Fried Food Intake with Gastric Cancer Risk: A Systemic Review and Meta-Analysis of Case–Control Studies

“…Frequent mealtime shifts over a long period increase the risk of H. pylori infection and gastritis [42]. A quantitative analysis of the relationship between irregular eating habits and gastric cancer in China showed that both irregular and fast eating were independent risk factors for gastric cancer (irregular eating: OR = 1.71, 95% CI: 1.62-1.91; fast eating: OR = 1.83; 95% CI: 1.71-2.01) [43]. It is common in Korea to enjoy eating fried chicken with beer as a late-night snack, and such habits could add to the risk of gastric cancer.…”

The Increasing Burden of Cancer Among Women and in Rural Areas: A Retrospective Population-Based Study

“…The top 3 to 6 common cancers are gastric, liver, colorectal, and esophageal cancers in Anhui Province, which are infection-related and poverty-related cancers. These cancers are associated with unhealthy lifestyles, such as alcohol consumption, 17 pickled foods, 18 eating hot food, 19 and chronic infectious agents. 20 In order to address this public health concern, the Huaihe Valley Cancer Early Diagnosis and Treatment Program has been providing screening services for upper gastrointestinal and liver cancers in Anhui Province since 2007.…”

Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment

“…However, antibiotics resistances steadily increase causing the therapy failure rates to keep climbing 2 . H. pylori may directly damage gastric epithelial cells through virulence factors and lead to many related gastric diseases 3 , while the population attributable risk percentage (PARP) of H. pylori was high up to 23.66% according to the epidemiological effect estimation for gastric cancer 4 . Moreover, H. pylori infection has a detrimental impact on the efficacy of cancer immunotherapies 5 .…”