Identification and localization of dopamine receptor subtypes in rat olfactory mucosa and bulb: a combined in situ hybridization and ligand binding radioautographic approach

Coronas, Valérie; Srivastava, Lalit K.; Liang, Jing-Jun; Jourdan, F; Moyse, Emmanuel

doi:10.1016/s0891-0618(97)00215-9

Cited by 86 publications

(67 citation statements)

References 60 publications

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“…The DA D2 receptor, but not the D1 receptor, is abundantly localized throughout the olfactory nerve layer and glomerular layer (Nickell et al, 1991;Coronas et al, 1997). Lesions of the olfactory nerve eliminate D2 receptor ligand binding in the theses layer.…”

Section: A Role For An Inducible Tyrosine Hydroxylase Enzymementioning

confidence: 96%

Odor-Induced, Activity-Dependent Transneuronal Gene InductionIn Vitro: Mediation by NMDA Receptors

Puché

Shipley

1999

J. Neurosci.

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Expression of tyrosine hydroxylase (TH) by juxtaglomerular (JG) neurons of the olfactory bulb (OB) requires innervation of the bulb by olfactory receptor neurons (ORNs). ORN lesion selectively downregulates TH in JG neurons. In reversible odor deprivation, TH expression is downregulated as the naris is closed and then upregulated upon naris reopening. The mechanism or mechanisms regulating this dependence are unknown. TH expression could be regulated by trophic factor release and/or synaptic activity from ORN terminals. We investigated TH expression in cocultures of dissociated postnatal rat OB cells and embryonic olfactory neuroepithelium (OE) slice explants. THpositive neurons in control dissociated OB cell cultures alone comprise only a small fraction of the total population of cells present in the culture. However, when OE slice explants are cocultured with dispersed OB cells, there is a mean 2.4-fold increase in the number of TH-positive neurons. ORNs in vivo use glutamate as a neurotransmitter. Broad spectrum excitatory amino acid antagonists (kyurenic acid) or selective antagonists of the NMDA receptor (APV) both prevent induction of TH expression in OE-OB cocultures. Furthermore, pulse application of NMDA stimulates TH expression in OB neurons in the absence of OE. In vitro, OB TH neurons express NMDA receptors, suggesting that NMDA stimulation is acting directly on TH neurons. Exposure of OE explants to natural odorants results in upregulation of TH, presumably through increased ORN activity, which could be blocked by APV. These findings indicate that odorant-stimulated glutamate release by ORN terminals regulates TH expression via NMDA receptors on JG dopaminergic neurons.

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Section: A Role For An Inducible Tyrosine Hydroxylase Enzymementioning

confidence: 96%

Odor-Induced, Activity-Dependent Transneuronal Gene InductionIn Vitro: Mediation by NMDA Receptors

Puché

Shipley

1999

J. Neurosci.

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“…We focused on effects of DA mediated by D 2 -like receptors, the main class of DA receptors in the OB (Nickell et al, 1991;Coronas et al, 1997;Duchamp-Viret et al, 1997;Davila et al, 2003;Gutièrrez-Mecinas et al, 2005). D 2 -like DA receptors have been detected on sensory afferents, MCs, and interneurons (Nickell et al, 1991;Coronas et al, 1997;Duchamp-Viret et al, 1997;Davila et al, 2003;Gutièrrez-Mecinas et al, 2005).…”

Section: Effects Of Da On Sensory Afferentsmentioning

confidence: 99%

Section: Effects Of Da On Sensory Afferentsmentioning

confidence: 99%

“…D 2 -like DA receptors have been detected on sensory afferents, MCs, and interneurons (Nickell et al, 1991;Coronas et al, 1997;Duchamp-Viret et al, 1997;Davila et al, 2003;Gutièrrez-Mecinas et al, 2005). On sensory afferents, D 2 -like receptors have been detected in mammals (Nickell et al, 1991;Coronas et al, 1997;Gutièrrez-Mecinas et al, 2005) but not in amphibians (Duchamp-Viret et al, 1997), suggesting that effects of DA on sensory input differ between species. In mammals and turtles, DA or agonists of D 2 -like receptors reduced MC responses to olfactory nerve stimulation via a presynaptic mechanism and decreased presynaptic calcium influx into sensory axon terminals (Hsia et al, 1999;Wachowiak and Cohen, 1999;Berkowicz and Trombley, 2000;Ennis et al, 2001;Maher and Westbrook, 2008).…”

Section: Effects Of Da On Sensory Afferentsmentioning

confidence: 99%

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Dopaminergic Modulation of Mitral Cells and Odor Responses in the Zebrafish Olfactory Bulb

Bundschuh

Zhu²,

Schärer³

et al. 2012

J. Neurosci.

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In the olfactory bulb, the modulatory neurotransmitter dopamine (DA) is coexpressed with GABA by local interneurons, but its role in odor processing remains obscure. We examined functions of DA mediated by D 2 -like receptors in the olfactory bulb of adult zebrafish by pharmacology, whole-cell recordings, calcium imaging, and optogenetics. Bath application of DA had no detectable effect on odorantevoked sensory input. DA directly hyperpolarized mitral cells (

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“…嗅觉系统中存在如μ受体等的所有阿片类受体的分布 (Kaufman et al, 1995)。fMRI（functional magnetic resonance imaging）实验表明, 急性注射海洛因后大鼠嗅皮层被广泛激活的现象能被μ受体的拮抗剂纳络酮逆转 (Xu et al, 2000)。中脑边缘-多巴胺系统在奖赏系统中有着至关重要的作用。嗅觉系统也广泛分布多巴胺(DA)能神经元 (Coronas et al, 1997), 从腹侧顶盖区域投射出来的多巴胺神经元广泛地投射到嗅结节。实验研究表明, 在大鼠的嗅结节局部注射可卡因可以诱导条件化位置偏好模型（conditioned place preference ， CPP ）的建立 (Ikemoto, 2003)。在解剖结构上, 哺乳动物嗅觉系统与高级皮层, 如眶额叶和边缘系统（如杏仁核、海马等区域）之间存在广泛联系 (Haberly, 2001;Savic, 2005)。大量实验表明, 海洛因或可卡因依赖者观看吸毒相关的影片、录像等引起渴求时, 额叶、边缘系统等皮层被激活 (Sinha et al, 2007;Bonson et al, 2002;Volkow et al, 2010) …”

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Effects of odor cue on morphine-induced dependence and craving in mice

Liu¹,

Yang²,

Yang³

et al. 2013

Zoological Research

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Abstract:The olfactory system may play a pivotal role in drug addiction. To clarify the issues, we investigated the morphine dependence and psychological craving in morphine addicted mice using the conditioned place preference (CPP) paradigm by taking an only odor cue as the conditioned stimulus (CS). The results showed that by pairing morphine with odor, the CPP could be induced in mice. When the morphine addicted mice were exposed to a novel environment during morphine withdrawal, they spent significantly longer time in the chamber with morphine-paired odor than in the control chamber. The effects of odor cue on the morphine CPP were blocked by the administration of dopamine D1 or D2 antagonists. The studies indicated that olfactory system plays an important role in drug addiction.

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Identification and localization of dopamine receptor subtypes in rat olfactory mucosa and bulb: a combined in situ hybridization and ligand binding radioautographic approach

Cited by 86 publications

References 60 publications

Odor-Induced, Activity-Dependent Transneuronal Gene InductionIn Vitro: Mediation by NMDA Receptors

Odor-Induced, Activity-Dependent Transneuronal Gene InductionIn Vitro: Mediation by NMDA Receptors

Dopaminergic Modulation of Mitral Cells and Odor Responses in the Zebrafish Olfactory Bulb

Effects of odor cue on morphine-induced dependence and craving in mice

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