Identification and management of cognitive disorders in multiple sclerosis

Lensch, Eckart; Matzke, Mike; Petereit, Hela-Felicitas; Scherer, P.; Schramm, Stefan; Calabrese, Pasquale

doi:10.1007/s00415-006-1107-x

Cited by 16 publications

(12 citation statements)

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“…In particular, cognitive functioning remained intact in 25 In summary, while it appears that over a sufficiently long follow-up period cognitive dysfunction is likely to emerge and progress, in general, great variation exists between longitudinal studies in the clinical variables of participants, length of follow-up, and neuropsychological methods, making it difficult to compare results. These methodological issues appear to be contributing to the conflicting data, and a consensus is yet to be achieved regarding the evolution of cognitive impairment in MS.…”

Section: Disease Durationmentioning

confidence: 95%

“…23,24 Despite the idiosyncrasies of the disease, specific domains of cognitive functioning appear particularly susceptible in MS. Learning and memory, conceptual reasoning, speed of information processing, attention, and executive functioning are most frequently affected. Language ability, including repetition, fluency and comprehension, is typically unaffected in MS. 1,5,17,23,25,26 A number of theorists have distinguished between the concepts of cortical and subcortical dementia, based on the relative differences in the location of neuropathology and the observed pattern of neuropsychological deficits. [27][28][29][30][31][32][33] Cortical dementia is characterized by profound losses in intelligence, resulting from amnesia, aphasia, apraxia, and agnosia, typified by the cortical grey matter atrophy occurring in Alzheimer's disease.…”

Section: Neuropsychological Profile Of Msmentioning

confidence: 99%

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Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations

Rogers

Panegyres

2007

Journal of Clinical Neuroscience

193

127

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Section: Disease Durationmentioning

confidence: 95%

Section: Neuropsychological Profile Of Msmentioning

confidence: 99%

Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations

Rogers

Panegyres

2007

Journal of Clinical Neuroscience

193

127

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“…The frequency of cognitive dysfunction has been estimated to be about 50% in the MS patient population [5,6,7]. Typically, cognitive speed is affected markedly and early in the disease course [4, 8, 9].…”

Section: Introductionmentioning

confidence: 99%

Selective Decline in Information Processing in Subgroups of Multiple Sclerosis: An 8-Year Longitudinal Study

Bergendal¹,

Fredrikson²,

Almkvist

2007

Eur Neurol

130

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Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS) that causes white matter and cortical lesions over many years. The CNS is selectively affected by the disease with a great variety of symptoms between patients. In this study, we describe the impact on various aspects of cognition over an 8-year follow-up period in 31 consecutive MS patients subgrouped as relapsing remitting (RR) MS, secondary progressive (SP) MS, and primary progressive (PP) MS. Results showed a differential pattern of cognitive decline already at baseline in speed of information processing. During the follow-up, a pronounced decline occurred in speed of information processing, finger-motor speed, copying geometrical designs, episodic memory, and visuospatial short-term memory. A striking difference was observed between a marked decline in visual reaction time, whereas no significant change was seen in auditory reaction time. In contrast, there was no time-related decline in verbal abilities. However, an initial marked cognitive impairment predicted further cognitive decline over the 8-year follow-up. Information-processing tests were found to be an especially strong predictor of long-term cognitive decline. In addition, high EDSS score at follow-up was associated with decline in information processes. Results also showed that SP-MS patients deteriorated significantly more than the other two groups, particularly in visual compared to auditory information processing. To conclude, cognitive decline appeared particularly in SP-MS patients and in visual information processing.

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“…Therefore, the assessment of cognitive functions is thought to be necessary in every patient undergoing a MS-related diagnostic evaluation [15]. Comprehensive cognitive testing is time consuming and requires qualified personnel.…”

Section: Cognitive Screening In Multiple Sclerosismentioning

confidence: 99%

“…Cognitive screening is performed to determine their likelihood of having a cognitive decline [10]. Those who have a positive result on the screening test will need further evaluation with subsequent comprehensive neuropsychological test batteries [15]. The goal of the screening is to detect cognitive disturbances at their earliest occurrence.…”

mentioning

confidence: 99%

Cognitive screening in multiple sclerosis

Scherer¹

2007

J Neurol

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Cognitive screening tests in multiple sclerosis (MS) are time- and cost-saving test instruments. In the case of a positive test result (alert function) a comprehensive cognitive test procedure should be administered. This paper explains what cognitive screening in MS means and presents several screening instruments used in MS with their statistical test characteristics, e. g. sensitivity and specificity.

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Identification and management of cognitive disorders in multiple sclerosis

Cited by 16 publications

References 0 publications

Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations

Cognitive impairment in multiple sclerosis: Evidence-based analysis and recommendations

Selective Decline in Information Processing in Subgroups of Multiple Sclerosis: An 8-Year Longitudinal Study

Cognitive screening in multiple sclerosis

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