Identification and Management of Fusobacterium Nucleatum Liver Abscess and Bacteremia in a Young Healthy Man

Cao, Shiliang Alice; Hinchey, Sherifat

doi:10.7759/cureus.12303

Cited by 2 publications

(3 citation statements)

References 20 publications

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“… AF atrial fibrillation, HTN hypertension, CAD coronary artery disease, DM diabetes mellitus, NA not-applicable, S sensitive, N/T: Not-tested. Case 1, 3, 5, 7 [ 7 ], case 2 [ 20 ], case 4 [ 21 ], case 6 [ 22 ], case 8 [ 4 ], case 9 [ 23 ], case 10 [ 24 ], case 11 [ 25 ], case 12 [ 26 ], case 13 [ 5 ] …”

Section: Discussionmentioning

confidence: 99%

A case report of severe Fusobacterium nucleatum sepsis secondary to nephrectomy

et al. 2022

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Background Fusobacterium nucleatum (F. nucleatum) is a resident anaerobic bacterium, which in rare cases may invade blood from the head and neck or the digestive tract to cause bacteremia and induce venous thrombosis. F. nucleatum is closely related to abdominal tumors, but it has not been reported in relation to renal tumors. We report herein a possible case. Case presentation This patient had kidney cancer with thrombosis in the right renal vein but had no sign of infection. After radical nephrectomy, thrombi formed in his left renal vein, and when removed, severe sepsis occurred. He did not respond to treatment with antibiotics and died, but the blood culture done confirmed that he had F. nucleatum bacteremia. Conclusion F. nucleatum may also be associated with kidney cancer, and could cause post-operative renal vein thrombosis, and sepsis or septic shock after thrombectomy.

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Section: Discussionmentioning

confidence: 99%

A case report of severe Fusobacterium nucleatum sepsis secondary to nephrectomy

et al. 2022

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“…4 Of note, increased procalcitonin has also been associated with PHA and extreme elevation (> 200 μg/L) may be a useful biomarker to identify F nucleatum infections before the presence of leukocytosis. 3 CT of PHA usually reveals right lobe involvement, and F nucleatum infection usually demonstrates multiple abscesses. 4,7 Contributing Factors in F nucleatum PHA F nucleatum is associated with several oral diseases, such as periodontitis and gingivitis.…”

Section: Pha Presentationmentioning

confidence: 99%

“…1 The incidence of PHA is reported to be 2.3 per 100,000 individuals and is more common in immunosuppressed individuals and those with diabetes mellitus, cancer, and liver transplant. 2,3 PHA infections are usually polymicrobial and most commonly include enteric organisms like Escherichia coli and Klebsiella pneumoniae. 4 We present a rare cause of PHA with Fusobacterium nucleatum (F nucleatum) in an immunocompetent patient with poor oral health, history of diverticulitis, and recent COVID-19 infection whose only symptoms were chest pain and a 4-week history of fever and malaise.…”

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confidence: 99%

Pyogenic Hepatic Abscess in an Immunocompetent Patient With Poor Oral Health and COVID-19 Infection

Vázquez¹

2023

Federal Practitioner

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Background: Pyogenic hepatic abscess (PHA) is a collection of pus in the liver caused by bacterial infection of the liver parenchyma. PHA is more common in immunosuppressed individuals and those with diabetes mellitus, cancer, and liver transplant. Case Presentation: We present a rare case of PHA with Fusobacterium nucleatum in an immunocompetent patient with poor oral health, history of diverticulitis, and recent COVID-19 infection whose only symptoms were chest pain and a 4-week history of fever and malaise. The source of infection in this patient was likely dental caries and periodontal disease, with COVID-19 infection playing a role as a red herring in this patient's disease progression, delaying diagnosis. Conclusions: Diagnosis and treatment of PHA must be prompt with drainage and empiric anaerobic coverage followed by a more tailored antibiotic regimen if indicated by culture and further drainage if indicated by computed tomography.

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Identification and Management of Fusobacterium Nucleatum Liver Abscess and Bacteremia in a Young Healthy Man

Cited by 2 publications

References 20 publications

A case report of severe Fusobacterium nucleatum sepsis secondary to nephrectomy

A case report of severe Fusobacterium nucleatum sepsis secondary to nephrectomy

Pyogenic Hepatic Abscess in an Immunocompetent Patient With Poor Oral Health and COVID-19 Infection

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