Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity

Kang, Hee Rae; Lee, Dahae; Eom, Hee Jeong; Lee, Seoung Rak; Lee, Kang Ro; Kang, Ki Sung; Kim, Ki‐Hyun

doi:10.1016/j.jff.2015.11.010

Cited by 30 publications

(16 citation statements)

References 44 publications

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“…The active ingredients of Sphagnum palustre were shown to treat cisplatin‐induced renal toxicity. The potential effect of S. palustre was by its ability in inhibiting the mitogen‐activated protein kinase response (Kang et al ., ). Colistin sodium methanesulfonate was reported to cause renal injury, which was confirmed by its action of changing the level of the antioxidant enzyme assay, plasma and renal enzyme markers.…”

Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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The liver is an important organ of the body, which has a vital role in metabolic functions. The non-steroidal anti-inflammatory drug (NSAID), diclofenac causes hepato-renal toxicity and gastric ulcers. NSAIDs are noted to be an agent for the toxicity of body organs. This review has elaborated various scientific perspectives of the toxicity caused by diclofenac and its mechanistic action in affecting the vital organ. This review suggests natural products are better remedies than current clinical drugs against the toxicity caused by NSAIDs. Natural products are known for their minimal side effects, low cost and availability. On the other hand, synthetic drugs pose the danger of adverse effects if used frequently or over a long period. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Natural Productsmentioning

confidence: 97%

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Simon

Sabina

2016

J of Applied Toxicology

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“…And the increased percentage of apoptotic cells by cisplatin was significantly decreased after cotreatment with the EtOH extract of S. palustre and ergosterol peroxide, (3β,22E,24S)-3hydroxyergosta-5,22-dien-7-one and betulinic acid and also, the protective potential effect of S. palustre was by its ability in inhibiting the mitogen-activated protein kinase response. 44 A study was carried out on Six-week-old BLAB/c male mice (weighing 20-25 g) and the spray-dried extracts of 239 products produced by 7 medicinal plants ((PD), (CM), LP, (SA), (CL), SB and (PS)) and they were screened to quantitatively determine the recovery effects of herbal medicines (HM) on the cisplatin-induced nephrotoxicity using cytotoxicity assays of cisplatintreated HEK 293 cells. And the results suggested that SB, CL, PS and SA are the best herbal medicines for the recovery of cisplatin-induced nephrotoxicity.…”

Section: Sphagnum Palustrementioning

confidence: 99%

Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity

Insaf¹,

Raju²

2019

IJPER

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Global trend is setting towards improved 'quality of life', for that there is considerable evidence of an increase in demand for medicinal plants. According to the WHO report, between 65% and 80% of the populations of developing countries use medicinal plants as remedy nowadays. Kidney is one of the vital organs of body and Nephrotoxicity is one of the most common problems and it occurs as a result when body is exposed to a drug or toxin. This review article aims to report and to introduce the effect of most important medicinal herbs, herbal formulations and some of the specific phytoconstituents that are used to prevent and treat anticancer, aminoglycoside, non-steroidal anti-inflammatory and few other classes of drug-induced nephrotoxicity. Particularly anti-cancer drugs among all other classes of drugs, cause high toxicity leading kidney damage and irreparable kidney injury. So, attention has recently been paid to seek out alternatives such as natural drugs that are effective and also less toxic. According to the studies carried out on different animals and cell line, many medicinal plants, herbal formulations and a few plant-based constituents by their antioxidant, free-radical and anti-inflammatory properties are found to be helpful in preventing drug-induced nephrotoxicity.

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“…In the meantime, a lot of inorganic drugs inspired by the anticancer effect of cisplatin ( cis ‐diamminedichloroplatinum(II)) have been designed and prepared by many experts [ 4,5 ] . Its anticancer activity mechanism is through the formation of adducts on interaction with deoxyribonucleic acid (DNA), hindering DNA transcription and replication [ 6–10 ] . Cisplatin has strong broad‐spectrum anticancer effects, such as against testicular cancer, breast cancer, lung cancer, head and neck cancer, ovarian cancer, osteosarcoma and melanoma [ 6,7 ] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of three novel butterfly‐like complexes with nitrogen‐containing heterocyclic ligands

Gao

Zhu

et al. 2020

Applied Organom Chemis

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Three novel complexes, namely [Nd·L1·HCOO·(H2O)4] (1), [Pr·L1·HCOO·(H2O)4] (2) and [In·L2·Cl·(H2O)2] (3) (L1 = 1,1‐bis(5‐(pyrazin‐2‐yl)‐1,2,4‐triazol‐3‐yl)methane, L2 = 1,1‐bis(5‐(pyrazin‐2‐yl)‐1,2,4‐triazol‐3‐yl)ketone), were synthesized and characterized. The molecular structures of 1–3 were confirmed using single‐crystal X‐ray diffraction. All three obtained complexes are zero‐dimensional and connected to each other by hydrogen bonds. In 1 and 2 the metal is surrounded by nine donors and 3 has seven coordination sites. The interaction of 1–3 with calf thymus DNA (CT‐DNA) was explored using UV absorption spectra and fluorescence spectra. The intrinsic binding constants of 1–3 with CT‐DNA are about 1.9 × 104, 1.4 × 104 and 1.1 × 104, respectively. Stern–Volmer quenching plots of 1–3 have slopes of 0.1508, 0.134 and 0.1205, respectively. The ability of these complexes to cleave pBR322 plasmid DNA was demonstrated using gel electrophoresis assay. Apoptosis studies of the three novel complexes showed a significant inhibitory effect on HeLa cells. Furthermore, MTT assays were used to evaluate the anticancer activity of the three complexes. The cytotoxicity study indicated that complex 1 possesses a higher inhibitory rate of HeLa cells than the other complexes. Especially, the efficacy of 1 was shown to be the highest for cisplatin at 24 h. A further molecular docking technique was introduced to understand the binding of the complexes toward the target DNA.

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Identification and mechanism of action of renoprotective constituents from peat moss Sphagnum palustre in cisplatin-induced nephrotoxicity

Cited by 30 publications

References 44 publications

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Natural remedies for non‐steroidal anti‐inflammatory drug‐induced toxicity

Potential of Pure Phytoconstituents and Herbs in Protection of Drug Induced Nephrotoxicity

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of three novel butterfly‐like complexes with nitrogen‐containing heterocyclic ligands

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