Infectious diseases caused by non-tuberculous mycobacteria (NTMB) are an important public health problem in most countries, increasing in recent years. The problem is both diagnosis, differential diagnosis with tuberculosis, and treatment. To study the data on NTMB, a review of scientific publications was carried out. Literature search was carried out using the RSCI, CyberLeninka, Scopus, Web of Science, MedLine, PubMed databases. To search for articles, such keywords as mycobacteriosis, non-tuberculous mycobacteria, HIV infection were used. Data on the prevalence of NTMB in different regions of the country were analyzed. The issues of diagnosis and treatment of mycobacteriosis are reflected.