Identification and preparation of stable water dispersions of protein - Carbon nanotube hybrids and efficient design of new functional materials

Giosia, Matteo Di; Valle, Francesco; Cantelli, Andrea; Bottoni, Andreà; Zerbetto, Francesco; Fasoli, Elisa; Calvaresi, Matteo

doi:10.1016/j.carbon.2019.02.043

Cited by 31 publications

(30 citation statements)

References 124 publications

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“…24,25 Because of their exceptional structural dimensions, 26 chemical and mechanical characteristics, 27 strong loading capacity 28 and biocompatibility, 29,30 both forms of CNTs namely single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT), were already employed as carrier materials for the attachment of enzymes by diverse procedures, such as direct physical adsorption 31,32 or covalent attachment. 33,34 For instance, with laccase, CNTs proved to have a high adsorption capacity 35,36 when compared to other carriers like silica, 37 spent grain 38 or coconut bre, 39 with a 333, 20 and 714 times higher adsorption capacity, respectively. Despite these promising results, to the best of our knowledge, up to now there are no previous reports about ASNase immobilization on pristine MWCNTs.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of a novel l-asparaginase/MWCNT nanobioconjugate

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Development and characterization of a novel l-asparaginase/MWCNT nanobioconjugate

et al. 2020

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“…The search for a protein as a good nanomolecule binder is reversed with respect to a search for a small ligand binder for which libraries are available [50]. Protein selection for a nanomolecule using high-throughput virtual screening or cheminformatics analysis are available [51,52].…”

Section: Introductionmentioning

confidence: 99%

Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins

Costanzo

Geremia

2020

Molecules

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Since the discovery of fullerene, carbon-based nanomolecules sparked a wealth of research across biological, medical and material sciences. Understanding the interactions of these materials with biological samples at the atomic level is crucial for improving the applications of nanomolecules and address safety aspects concerning their use in medicine. Protein crystallography provides the interface view between proteins and carbon-based nanomolecules. We review forefront structural studies of nanomolecules interacting with proteins and the mechanism underlying these interactions. We provide a systematic analysis of approaches used to select proteins interacting with carbon-based nanomolecules explored from the worldwide Protein Data Bank (wwPDB) and scientific literature. The analysis of van der Waals interactions from available data provides important aspects of interactions between proteins and nanomolecules with implications on functional consequences. Carbon-based nanomolecules modulate protein surface electrostatic and, by forming ordered clusters, could modify protein quaternary structures. Lessons learned from structural studies are exemplary and will guide new projects for bioimaging tools, tuning of intrinsically disordered proteins, and design assembly of precise hybrid materials.

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“…In particular, carbon nanotubes (CNTs) are one-dimensional (1-D) carbon nanoparticles having excellent electrical, thermal and mechanical proprieties. It is known that CNTs may interact with proteins and living organisms (Long et al, 2012;Calvaresi and Zerbetto, 2013;Wang et al, 2013;Dewi et al, 2015;Lukhele et al, 2015;Thakkar et al, 2016;Di Giosia et al, 2019; however, most of the work is limited to the study of their toxicity and does not explore their use as an additive to obtain new materials. The inclusion of CNM into plants, their organelles, and organelle components has the potential to enhance their functions (Faltermeier et al, 2014;Wong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A Plant Bioreactor for the Synthesis of Carbon Nanotube Bionic Nanocomposites

Magnabosco

Pantano

Rapino

et al. 2020

Front. Bioeng. Biotechnol.

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Bionic composites are an emerging class of materials produced exploiting living organisms as reactors to include synthetic functional materials in their native and highly performing structures. In this work, single wall carboxylated carbon nanotubes (SWCNT-COOH) were incorporated within the roots of living plants of Arabidopsis thaliana. This biogenic synthetic route produced a bionic composite material made of root components and SWCNT-COOH. The synthesis was possible exploiting the transport processes existing in the plant roots. Scanning electrochemical microscopy (SECM) measurements showed that SWCNT-COOH entered the vascular bundles of A. thaliana roots localizing within xylem vessels. SWCNT-COOH preserved their electrical properties when embedded inside the root matrix, both at a microscopic level and a macroscopic level, and did not significantly affect the mechanical properties of A. thaliana roots.

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Identification and preparation of stable water dispersions of protein - Carbon nanotube hybrids and efficient design of new functional materials

Cited by 31 publications

References 124 publications

Development and characterization of a novel l-asparaginase/MWCNT nanobioconjugate

Development and characterization of a novel l-asparaginase/MWCNT nanobioconjugate

Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins

A Plant Bioreactor for the Synthesis of Carbon Nanotube Bionic Nanocomposites

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