Identification and quality evaluation of Chinese rice wine using UPLC-PDA-QTOF/MS with dual-column separation

Zheng, Xunhua; Liu, Shundi; Qiu, Jieying; Lin, Hui; Li, Dan; Jiang, Jianping

doi:10.1016/j.phymed.2022.154498

Cited by 5 publications

(1 citation statement)

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“…However, it is important to consider the potential toxicity of 5-HMF, which primarily causes nephrotoxicity through oxidative stress, energy metabolism disorders, purine metabolism disorders, and amino acid metabolism imbalances. Although specific limits are not specified, a glucose content above 0.02% should alert the manufacturer [33]. Uracil has been found to possess bactericidal, antiviral, and anti-tumor effects [34,35].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Fermentation on the Chemical Constituents of Gastrodia Tuber Hallimasch Powder (GTHP) Estimated by UHPLC-Q-Orbitrap HRMS and HPLC

Wu,

Zhang,

Zhu

et al. 2024

Molecules

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Objective: To compare the effect of fermentation on the chemical constituents of Gastrodia Tuder Halimasch Powder (GTHP), to establish its fingerprinting and multicomponent content determination, and to provide a basis for the processing, handling, and clinical application of this herb. Methods: Ultra-high-performance liquid chromatography-quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was used to conduct a preliminary analysis of the chemical constituents in GTHP before and after fermentation. High-performance liquid chromatography (HPLC) was used to determine some major differential components of GTHP and establish fingerprints. Cluster analysis (CA), and principal component analysis (PCA) were employed for comprehensive evaluation. Results: Seventy-nine compounds were identified, including flavonoids, organic acids, nucleosides, terpenoids, and others. The CA and PCA results showed that ten samples were divided into three groups. Through standard control and HPLC analysis, 10 compounds were identified from 22 peaks, namely uracil, guanosine, adenosine, 5-hydroxymethylfurfural (5-HMF), daidzin, genistin, glycitein, daidzein, genistein, and ergosterol. After fermentation, GTHP exhibited significantly higher contents of uracil, guanosine, adenosine, 5-hydroxymethylfurfural, and ergosterol and significantly lower genistein and daidzein contents. Conclusions: The UHPLC-Q-Orbitrap HRMS and HPLC methods can effectively identify a variety of chemical components before and after the fermentation of GTHP. This study provides a valuable reference for further research on the rational clinical application and quality control improvement of GTHP.

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Section: Discussionmentioning

confidence: 99%