Identification and quantification of free, esterified, glycosylated and insoluble-bound phenolic compounds in hawthorn berry fruit (Crataegus pinnatifida) and antioxidant activity evaluation

Lou, Xinman; Xu, Huaide; Hanna, Milford A.; Yuan, Long

doi:10.1016/j.lwt.2020.109643

Cited by 49 publications

(18 citation statements)

References 33 publications

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“…At the same time, these extracts showed no cytotoxic effects on healthy colon epithelial cells [ 45 ] and normal human peripheral mononuclear cells [ 46 ]. Additionally, the anti-oxidant activity of the phenolic composition and individual compounds from Crataegus pinnatifida berries [ 47 ], Crataegus monogyna leaves [ 48 ], and Crataegus oxyacantha flowers and berries [ 49 ] were described. The recent reports showed mild cytotoxic effects of phenolic acids from Petroselinum crispum L. on human U87MG cells [ 22 ], flavonoids from Lippa graveolens on human U251MG cells [ 23 ], and anthocyanins from Rubus liebmannii and Rubus palmeri on C6 and RG2 rat and murine, respectively, glioma cell lines [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

et al. 2021

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Crataegus contains numerous health-promoting compounds that are also proposed to have anti-cancer properties. Herein, we aimed at a contemporaneous evaluation of the effects of polyphenol-rich extracts of berries, leaves, and flowers of six Crataegus species on the viability and invasive potential on the highly aggressive human glioblastoma U87MG cell line. The treatment with the extracts evoked cytotoxic effects, with the strongest in the berry extracts. All extracts not only promoted the apoptosis-related cleavage of poly (ADP-ribose) polymerase 1 (PARP1) but also substantially inhibited the activity of pro-survival kinases, focal adhesion kinase (FAK), and protein kinase B (PKB; also known as Akt), thus indicating the suppression of proliferative and invasive potentials of the examined glioblastoma cells. The qualitative and quantitative characterization of the extracts’ content was also performed and revealed that amongst 37 polyphenolic compounds identified in the examined Crataegus extracts, the majority (29) was detected in berries; the leaf and flower extracts, exerting milder cytotoxic effects, contained only 14 and 13 compounds, respectively. The highest polyphenol content was found in the berries of C. laevigata x rhipidophylla x monogyna, in which flavan-3-ols and phenolic acids predominated. Our results demonstrated that a high content of polyphenolic compounds correlated with the extract cytotoxicity, and especially berries were a valuable source of compounds with anti-cancer potential. This might be a promising option for the development of an effective therapeutic strategy against highly malignant glioblastomas in the future.

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Section: Discussionmentioning

confidence: 99%

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

et al. 2021

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“…Quercetin and isorhamnetin were found to be always present in all red-skinned species in this study. Luteolin has been identified in both Chinese hawthorn [11] and blackberry [12] in recent studies.…”

Section: Resultsmentioning

confidence: 98%

In silico screening of potential anti–COVID-19 bioactive natural constituents from food sources by molecular docking

Gao

Liang³

et al. 2021

Nutrition

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Highlights Screen potential anti-COVID-19 bioactive natural ingredients from food sources through high-throughput molecular docking. Quercetin, Luteolin and Isorhamnetin as antiviral active phytocompounds Red wine, Chinese hawthorn and blackberry are rich dietary sources of polyphenols with reported health benefits, and they are recommended as preventive supplements

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“…É sabido que os compostos fenólicos são os principais componentes bioativos responsáveis pela atividade antioxidante das frutas (Ge et al, 2021;Lou et al, 2020), e, diante dos seus benefícios, passaram a ser explorados em diversas áreas. Por exemplo, sua incorporação à dieta de consumidores que procuram alimentos funcionais (Pogačnik, Ota & Ulrih, 2020), além de representarem uma boa alternativa aos antioxidantes sintéticos nas indústrias de alimentos e medicamentos, por ser considerado um ingrediente seguro (Olszowy, 2019;Food Ingredients & Packaging, 2019).…”

Section: Resultsunclassified

Aumento da atividade anticoagulante da varfarina e sua potencial interação com o extrato aquoso de goji berry (Lycium barbarum L.) em ratos Wistar

Oliveira

Camilo

Marques

et al. 2020

RSD

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O consumo de goji berry (Lycium barbarum L.) tem despertado interesse mundial devido suas excelentes propriedades nutricionais e funcionais, relacionada à diminuição do risco de desenvolvimento de doenças crônicas decorrentes do estresse oxidativo, o classifica como um “super alimento”. Assim, o objetivo deste estudo foi avaliar os efeitos do extrato aquoso de goji berry nos parâmetros hematológicos e bioquímicos em ratos Wistar tratados com varfarina. A concentração de fenóis totais foi determinada pelo reagente Folin-Ciocalteau, enquanto a capacidade antioxidante determinada pelo ensaio DPPH. Os animais foram distribuídos em quatro grupos experimentais: água destilada (veículo – controle negativo); alimentados diariamente com o extrato (0,18 g.Kg-1); tratados diariamente com água destilada e varfarina (0,5 mg.Kg-1 – controle positivo) e aqueles tratados concomitantemente com o extrato e varfarina, durante sete dias. Nossos resultados demonstraram elevada quantidade de polifenóis (6,19 ± 0,3 mg EAG.g-1) no extrato aquoso a 10 % (m.v-1) e sugerem considerável atividade antioxidante (IC50 1068 µg.mL-1). Não observamos diferenças significativas entre os perfis bioquímicos e hematológicos, ou sequer sinais de toxicidade do extrato quando administrado sozinho. Os dados provenientes do uso concomitante com a varfarina são impressionantes e mostram aumento significante no tempo de protombina, com a potencialidade de sangramento. Coletivamente, essas observações sugerem a propensão de uma interação clinicamente importante entre a varfarina e o Lycium barbarum L., o que compromete a segurança deste medicamento e lança luz para pesquisas futuras relacionadas a uma compreensão mais profunda dos mecanismos moleculares envolvidos.

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Identification and quantification of free, esterified, glycosylated and insoluble-bound phenolic compounds in hawthorn berry fruit (Crataegus pinnatifida) and antioxidant activity evaluation

Cited by 49 publications

References 33 publications

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

In silico screening of potential anti–COVID-19 bioactive natural constituents from food sources by molecular docking

Aumento da atividade anticoagulante da varfarina e sua potencial interação com o extrato aquoso de goji berry (Lycium barbarum L.) em ratos Wistar

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