Identification and quantification of linear and branched isomers of perfluorooctanoic and perfluorooctane sulfonic acids in contaminated groundwater in the veneto region

Pellizzaro, Alessandro; Zaggia, Alessandro; Fant, Massimo; Conte, L.; Falletti, Luigi

doi:10.1016/j.chroma.2017.12.036

Cited by 24 publications

(20 citation statements)

References 21 publications

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“…We quantified branched isomers for PFOS, PFOA, PFNA, and PFHxS using calibration standards for the linear isomers, assuming the same instrumental response factor, following previous work (Pellizzaro et al. 2018; Ullah et al.…”

Section: Methodsmentioning

confidence: 99%

Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women

Tokranov

Liddie

et al. 2019

Environ Health Perspect

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Background:Between 2013 and 2015, concentrations of poly- and perfluoroalkyl substances (PFAS) in public drinking water supplies serving at least six million individuals exceeded the level set forth in the health advisory established by the U.S. Environmental Protection Agency. Other than data reported for contaminated sites, no systematic or prospective data exist on the relative source contribution (RSC) of drinking water to human PFAS exposures.Objectives:This study estimates the RSC of tap water to overall PFAS exposure among members of the general U.S. population.Methods:We measured concentrations of 15 PFAS in home tap water samples collected in 1989–1990 from 225 participants in a nationwide prospective cohort of U.S. women: the Nurses’ Health Study (NHS). We used a one-compartment toxicokinetic model to estimate plasma concentrations corresponding to tap water intake of PFAS. We compared modeled results with measured plasma PFAS concentrations among a subset of 110 NHS participants.Results:Tap water perfluorooctanoic acid (PFOA) and perfluorononanoic acid (PFNA) were statistically significant predictors of plasma concentrations among individuals who consumed ≥8 cups of tap water per day. Modeled median contributions of tap water to measured plasma concentrations were: PFOA 12% (95% probability interval 11%–14%), PFNA 13% (8.7%–21%), linear perfluorooctanesulfonic acid (nPFOS) 2.2% (2.0%–2.5%), branched perfluorooctanesulfonic acid (brPFOS) 3.0% (2.5%–3.2%), and perfluorohexanesulfonic acid (PFHxS) 34% (29%–39%). In five locations, comparisons of PFASs in community tap water collected in the period 2013–2016 with samples from 1989–1990 indicated increases in quantifiable PFAS and extractable organic fluorine (a proxy for unquantified PFAS).Conclusions:Our results for 1989–1990 compare well with the default RSC of 20% used in risk assessments for legacy PFAS by many agencies. Future evaluation of drinking water exposures should incorporate emerging PFAS. https://doi.org/10.1289/EHP4093

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Section: Methodsmentioning

confidence: 99%

Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women

Tokranov

Liddie

et al. 2019

Environ Health Perspect

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“…To access the final edited and published work see https://doi.org/10.1021/acs.analchem.0c01591 provides ample evidence of similar structural motifs. In this case, the major plausible possibility is that species could differ in terms of chain branching, with branched isomers eluting prior to straight-chain PFAS 43 , indeed, the latest eluting species and dominant peak (Figure 6) was confirmed as the non-branched form using a deuterated standard (supplemental validation excel file). Future studies might distinguish branched isomers using MS 3 approaches.…”

Section: Iterative-exclusion Data-dependent Analysis and Data-independent Analysismentioning

confidence: 98%

Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition

et al. 2020

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Thousands of per-and polyfluoroalkyl substances (PFAS) exist in the environment and pose a potential health hazard. Suspect and non-target screening with liquid chromatography (LC) high-resolution tandem mass spectrometry (HRMS/MS) can be used for comprehensive characterization of PFAS. To date no automated open source PFAS data analysis software exists to mine these extensive datasets. We introduce FluoroMatch, which automates file conversion, chromatographic peak picking, blank feature filtering, PFAS annotation based on precursor and fragment masses, and annotation ranking. The software library currently contains ~7,000 PFAS fragmentation patterns based on rules derived from standards and literature and the software This document is the postprint version of an article published in

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“…PFOA and PFOS are two PFASs most commonly used in the industry and the most commonly determined PFASs in living organisms and the environment. Their prevalence and long-distance migration are evidenced by data regarding their presence in soil [110,111]; air [112], including Arctic air [113]; groundwater [114]; deposits [115]; snow in regions, including the Antarctic [116]; and rain water and surface water [117]. Due to their amphophilic properties, PFASs relatively easily migrate to the aquatic environment [65].…”

Section: Abioticmentioning

confidence: 99%

Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)—A Synthesis of Current Knowledge with Proposal of Molecular Mechanism

Mokra

2021

IJMS

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Endocrine disruptors are a group of chemical compounds that, even in low concentrations, cause a hormonal imbalance in the body, contributing to the development of various harmful health disorders. Many industry compounds, due to their important commercial value and numerous applications, are produced on a global scale, while the mechanism of their endocrine action has not been fully understood. In recent years, per- and polyfluoroalkyl substances (PFASs) have gained the interest of major international health organizations, and thus more and more studies have been aimed to explain the toxicity of these compounds. PFASs were firstly synthesized in the 1950s and broadly used in the industry in the production of firefighting agents, cosmetics and herbicides. The numerous industrial applications of PFASs, combined with the exceptionally long half-life of these substances in the human body and extreme environmental persistence, result in a common and chronic exposure of the general population to their action. Available data have suggested that human exposure to PFASs can occur during different stages of development and may cause short- or/and long-term health effects. This paper synthetizes the current literature reports on the presence, bioaccumulation and, particularly, endocrine toxicity of selected long- and short-chain PFASs, with a special emphasis on the mechanisms underlying their endocrine actions.

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Identification and quantification of linear and branched isomers of perfluorooctanoic and perfluorooctane sulfonic acids in contaminated groundwater in the veneto region

Cited by 24 publications

References 21 publications

Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women

Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women

Toward Comprehensive Per- and Polyfluoroalkyl Substances Annotation Using FluoroMatch Software and Intelligent High-Resolution Tandem Mass Spectrometry Acquisition

Endocrine Disruptor Potential of Short- and Long-Chain Perfluoroalkyl Substances (PFASs)—A Synthesis of Current Knowledge with Proposal of Molecular Mechanism

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