Identification and quantitative analysis of β-cryptoxanthin and β-citraurin esters in Satsuma mandarin fruit during the ripening process

Ma, Gang; Zhang, Lancui; Iida, Kohei; Madono, Yuki; Yungyuen, Witchulada; Yoshio, Masaki; Yamawaki, Kazuki; Kato, Masaaki

doi:10.1016/j.foodchem.2017.05.015

Cited by 35 publications

(27 citation statements)

References 37 publications

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“…One important source of BCX in the human diet are mandarins which is esterified with a variety of fatty acids in a high proportion [8,12]. Analysis of carotenoid composition in the juice extract of Clementine mandarin showed that BCX was the main carotenoid accounting for nearly 60% of the total carotenoid content and being 90% in esterified form (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…In fact, clinical studies indicated that seasonal intake of citrus fruits in many populations significantly increases plasma levels of BCX and its concentration is considered to be a biomarker of citrus fruit consumption [3,10]. Interestingly, the preferential natural accumulating form of BCX in the flesh of ripen citrus fruit is esterified with lauric, myristic, and palmitic acid, and only a minor proportion—ranging from less than 5% up to 20%—remains in free form [11,12].…”

Section: Introductionmentioning

confidence: 99%

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β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

et al. 2019

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β-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The Caenorhabditis elegans model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 µg/mL) (p < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and β-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

et al. 2019

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“…Esterification of carotenoids can promote their sequestration and improve their storage stability in wheat and might also reduce carotenoid degradation in citrus fruits [250][251][252][253]. Post-harvest carotenoid stability can be also improved by enhancing the antioxidant capacity of the target tissue.…”

Section: Metabolic Engineering Strategies For Carotenoid Biofortificamentioning

confidence: 99%

Carotenoid biofortification in crop plants: citius, altius, fortius

Zheng

Giuliano

Al‐Babili

2020

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Consequently, it does not require enzymatic digestion prior to intestinal absorption. However, the dietary xanthophylls (viz., β‐cryptoxanthin, LUT, and ZEA) are found in foods in unesterified form and as fatty acyl monoesters, and in the cases of LUT and ZEA as diesters . The relative amounts of xanthophyll esters versus free xanthophylls differ among various dietary sources.…”

Section: Intestinal Absorption Of Vitamin a And Carotenoidsmentioning

confidence: 99%

Mechanisms of Transport and Delivery of Vitamin A and Carotenoids to the Retinal Pigment Epithelium

Harrison

2019

Molecular Nutrition Food Res

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Vision depends on the delivery of vitamin A (retinol) to the retina. Retinol in blood is bound to retinol‐binding protein (RBP). Retinal pigment epithelia (RPE) cells express the RBP receptor, STRA6, that facilitates uptake of retinol. The retinol is then converted to retinyl esters by the enzyme lecithin:retinol acyltransferase. The esters are the substrate for RPE65, an enzyme that produces 11‐cis retinol, which is converted to 11‐cis retinaldehyde for transport to the photoreceptors to form rhodopsin. The dietary xanthophylls, lutein (LUT) and zeaxanthin (ZEA), accumulate in the macula of the eye, providing protection against age‐related macular degeneration. To reach the macula, carotenoids cross the RPE. In blood, xanthophylls and β‐carotene mostly associate with high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL), respectively. Studies using a human RPE cell model evaluate the kinetics of cell uptake when carotenoids are delivered in LDL or HDL. For LUT and β‐carotene, LDL delivery result in the highest rate of uptake. HDL is more effective in delivering ZEA (and meso‐ZEA). This selective HDL‐mediated uptake of ZEA, via a scavenger receptor and LDL‐mediated uptake of LUT and β‐carotene provides a mechanism for the selective accumulation of ZEA > LUT and xanthophylls over β‐carotene in the macula.

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Identification and quantitative analysis of β-cryptoxanthin and β-citraurin esters in Satsuma mandarin fruit during the ripening process

Cited by 35 publications

References 37 publications

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in Caenorhabditis elegans Model

Carotenoid biofortification in crop plants: citius, altius, fortius

Mechanisms of Transport and Delivery of Vitamin A and Carotenoids to the Retinal Pigment Epithelium

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