Identification and S-metolachlor-safening Effects of Compounds Extracted from Ligusticum chuanxiong on Rice

Li, Jingbo; Zheng, Wei; Wang, Yanhui; Cai, Hailin; Jin, Chenzhong; Liu, Xiu; Bai, Lianyang

doi:10.17957/ijab/15.0153

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Notably, Z-ligustilide possessed better activity than senkyunolide A, and both of them displayed superior recovery benefits for shoots compared to roots. 57,58 N-Alkyl Amide Natural Products for Chloroacetamide Herbicides. Szechuan peppers (Zanthoxylum bungeanum Maxim) have been utilized for their pharmaceutical and gastronomic advantages, and their predominant active components are sanshools.…”

Section: Herbicide Safenersmentioning

confidence: 99%

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Review on the Discovery of Novel Natural Herbicide Safeners

Leng

Zhao

Gao

et al. 2023

J. Agric. Food Chem.

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The phytotoxicity of herbicides on crops is a major dilemma in agricultural production. Fortunately, the emergence of herbicide safeners is an excellent solution to this challenge, selectively enhancing the performance of herbicides in controlling weeds while reducing the phytotoxicity to crops. But owing to their potential toxicity, only a tiny proportion of safeners are commercially available. Natural products as safeners have been extensively explored, which are generally safe to mammals and cause little pollution to the environment. They are typically endogenous signal molecules or phytohormones, which are generally difficult to extract and synthesize, and exhibit relatively lower activity than commercial products. Therefore, it is necessary to adopt rational design approaches to modify the structure of natural safeners. This paper reviews the application, safener effects, structural characteristics, and modifications of natural safeners and provides insights on the discovery of natural products as potential safeners in the future.

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Section: Herbicide Safenersmentioning

confidence: 99%

“…Similar to commercial safeners, the extracts increased the activity of GSTs in rice, thus providing a safener effect. Notably, Z -ligustilide possessed better activity than senkyunolide A, and both of them displayed superior recovery benefits for shoots compared to roots. , …”

Section: Potential Use Of Natural Products As Herbicide Safenersmentioning

confidence: 99%

Review on the Discovery of Novel Natural Herbicide Safeners

Leng

Zhao

Gao

et al. 2023

J. Agric. Food Chem.

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“…The primary mechanism for safener action is the enhancement of herbicide detoxification in safened plants [21]. The ability of safeners to enhance glutathione S-transferase (GST) activity has been particularly well described in rice, maize, and wheat, among other crops [25][26][27]. In these cases, safener treatments may induce transcriptional activation of specific GST genes and enhance the glutathione S-transferase (GST) expression of the respective enzymes that catalyze the conjugation of herbicides with glutathione (GSH) in crop plants to detoxify them [28].…”

Section: Introductionmentioning

confidence: 99%

“…Besides, hydroxy-α-sanshool may also block KCNK9 channels to induce colonic motor activity in the rat proximal colon [36]. Naturally occurring products provide an excellent basis for the discovery of novel pesticides, including insecticides, fungicides, herbicides, and even herbicide safeners [18,25,37,38]. In our previous study, a mixture of sanshools consisting of hydroxy-α/β/ε-sanshool, α/β/ε-sanshool, γ-sanshool, hydroxyl-γ-sanshool, dehydro-γ-sanshool, and dihydroxy-α/β-sanshool (Figure 1) was extracted from Szechuan pepper fruits by the supercritical fluid extraction (SFE) method.…”

Section: Introductionmentioning

confidence: 99%

New Lead Discovery of Herbicide Safener for Metolachlor Based on a Scaffold-Hopping Strategy

et al. 2020

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The use of herbicide safeners can significantly alleviate herbicide injury to protect crop plants and expand the application scope of the existing herbicides in the field. Sanshools, which are well known as spices, are N-alkyl substituted compounds extracted from the Zanthoxylum species and have several essential physiological and pharmacological functions. Sanshools display excellent safener activity for the herbicide metolachlor in rice seedlings. However, the high cost of sanshools extraction and difficulties in the synthesis of their complicated chemical structures limit their utilization in agricultural fields. Thus, the present study designed and synthesized various N-alkyl amide derivatives via the scaffold-hopping strategy to solve the challenge of complicated structures and find novel potential safeners for the herbicide metolachlor. In total, 33 N-alkyl amide derivatives (2a–k, 3a–k, and 4a–k) were synthesized using amines and saturated and unsaturated fatty acids as starting materials through acylation and condensation. The identity of all the target compounds was well confirmed by 1H-NMR, 13C-NMR, and high-resolution mass spectrometry (HRMS). The primary evaluation of safener activities for the compounds by the agar method indicated that most of the target compounds could protect rice seedlings from injury caused by metolachlor. Notably, compounds 2k and 4k displayed excellent herbicide safener activities on plant height and demonstrated relatively similar activities to the commercialized compound dichlormid. Moreover, we showed that compounds 2k and 4k had higher glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and polyphenol oxidase (PPO) activities in rice seedlings, compared to the metolachlor treatment. In particular, 2k and 4k are safer for aquatic organisms than dichlormid. Results from the current work exhibit that compounds 2k and 4k have excellent crop safener activities toward rice and can, thus, be promising candidates for further structural optimization in rice protection.

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Current Advances in the Action Mechanisms of Safeners

Deng

2022

Agronomy

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Herbicide safeners are a series of agrochemicals that can selectively protect crop plants from herbicide injury without affecting herbicidal efficacy. Understanding mechanisms by which safeners act is significant for discovery of novel types. Safeners primarily alleviate herbicide phytotoxicity to crop plants via several actions: (i) enhancing metabolism of herbicides in crops; (ii) affecting absorption and transportation of herbicides in crops; (iii) competitively binding to herbicide target sites; and (iv) affecting activity of target enzymes. This review describes recent advances in the action mechanisms of safeners, analyzes existing problems, anticipates the future direction of studies of modes of action of safeners, and prospects potential strategies to design safeners related to their reported mechanisms. The aim of this paper is to provide insight into mechanisms of safeners and give tips for development of new safeners.

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Identification and S-metolachlor-safening Effects of Compounds Extracted from Ligusticum chuanxiong on Rice

Cited by 4 publications

References 25 publications

Review on the Discovery of Novel Natural Herbicide Safeners

Review on the Discovery of Novel Natural Herbicide Safeners

New Lead Discovery of Herbicide Safener for Metolachlor Based on a Scaffold-Hopping Strategy

Current Advances in the Action Mechanisms of Safeners

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