Identification and treatment of individuals with childhood-onset and early-onset schizophrenia

Correll, Christoph U.; Arango, Celso; Fagerlund, Birgitte; Galderisi, Silvana; Kas, Martien J.; Leucht, Stefan

doi:10.1016/j.euroneuro.2024.02.005

European Neuropsychopharmacology

2024

DOI: 10.1016/j.euroneuro.2024.02.005

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Identification and treatment of individuals with childhood-onset and early-onset schizophrenia

Christoph U. Correll,

Celso Arango,

Birgitte Fagerlund

et al.

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2024

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Cited by 3 publications

References 178 publications

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Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data

De las Cuevas,

Sanz,

Jiménez-Fernández

et al. 2024

Eur Child Adolesc Psychiatry

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Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data

De las Cuevas,

Sanz,

Jiménez-Fernández

et al. 2024

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Schizophrenia spectrum disorders in children and adolescents: Clinical, phenomenological, diagnostic, and prognostic features across subtypes

Poletti,

Raballo

2024

Schizophrenia Research

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Severe necrotic colitis in an adolescent with polypharmacy and high clozapine doses according to his ancestry.

Baptista,

de Leon,

Guizar

et al. 2024

Investigación Clínica

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The antipsychotic drug Clozapine (CLZ) is approved for treat-ment-resistant schizophrenia and reduction in the risk of recurrent suicidal behavior in schizophrenia or schizoaffective disorder. However, it is increasingly used in psychiatry and neurology worldwide in numerous off-label conditions. Clozapine is associated with diverse side effects which require careful monitor-ing in its use for prevention and treatment. The quality of CLZ use and pharma-covigilance varies considerably among Latin American countries. CLZ-induced gastrointestinal hypomotility (CIGH) is a relevant clinical problem, ranging from innocuous constipation to lethal necrotic colitis. Thus, optimal preven-tion, early detection, and treatment of CIGH deserves considerable attention. We describe here the case of a 15-year-old Mexican boy diagnosed with Opposi-tional Defiant- and Attention-Deficit/Hyperactivity Disorder who developed se-vere necrotic colitis after nine months of CLZ treatment, leading to permanent ileostomy. We ascribed this unfortunate outcome to careless polypharmacy that did not consider drug-related antimuscarinic activity, deficient clinical moni-toring, and lack of attention to ethnicity concerning drug dosing. This case is of educational value for the mental health team in order to promote the proper use of CLZ, which may be life-saving in patients with severe mental disorders.

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Identification and treatment of individuals with childhood-onset and early-onset schizophrenia

Cited by 3 publications

References 178 publications

Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data

Evaluating the adverse drug reactions to clozapine in populations of children and adolescents: insights from VigiBase data

Schizophrenia spectrum disorders in children and adolescents: Clinical, phenomenological, diagnostic, and prognostic features across subtypes

Severe necrotic colitis in an adolescent with polypharmacy and high clozapine doses according to his ancestry.

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