Identification and validation of a novel ferroptosis-related gene model for predicting the prognosis of gastric cancer patients

Liu, Gang; Ma, Jianying; Hu, Gang; Jin, Huan

doi:10.1371/journal.pone.0254368

Cited by 10 publications

(9 citation statements)

References 51 publications

(56 reference statements)

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“…Currently, surgery, chemotherapy, and targeted therapy have been widely used for CRC treatment, whereas some patients still exhibit resistance to these therapies [90]. A recent study confirmed that ferroptosis might be a substitute strategy for killing chemotherapy-resistant CRC cells [70]. In addition, mounting evidence suggests that ferroptosis-related genes could be used as biomarkers to predict CRC (Table 3).…”

Section: The Role Of Ferroptosis In Colorectal Cancer (Crc)mentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

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Ferroptosis is a novel form of regulated cell death (RCD) that is typically accompanied by iron accumulation and lipid peroxidation. In contrast to apoptosis, autophagy, and necroptosis, ferroptosis has unique biological processes and pathophysiological characteristics. Since it was first proposed in 2012, ferroptosis has attracted attention worldwide. Ferroptosis is involved in the progression of multiple diseases and could be a novel therapeutic target in the future. Recently, tremendous progress has been made regarding ferroptosis and gastrointestinal diseases, including intestinal ischemia/reperfusion (I/R) injury, inflammatory bowel disease (IBD), gastric cancer (GC), and colorectal cancer (CRC). In this review, we summarize the recent progress on ferroptosis and its interaction with gastrointestinal diseases. Understanding the role of ferroptosis in gastrointestinal disease pathogenesis could provide novel therapeutic targets for clinical treatment.

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Section: The Role Of Ferroptosis In Colorectal Cancer (Crc)mentioning

confidence: 99%

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Liu

Xiao

2021

IJMS

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“…FRGs-based signatures had been identified with prognostic values in colon cancer, [ 51 ] lung adenocarcinoma, [ 52 , 53 ] gastric cancer, [ 54 ] breast cancer, [ 55 ] and bladder cancer. [ 21 , 56 ] And nomograms built by FRGs for predicting survival probabilities had already been used in lung adenocarcinoma and oral squamous cell carcinoma patients.…”

Section: Discussionmentioning

confidence: 99%

A five ferroptosis-related genes risk score for prognostic prediction of osteosarcoma

Song

2022

Medicine

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Background: Osteosarcoma (OS) is the most common bone cancer in adolescents, and has a high propensity to metastasize. Ferroptosis is a unique modality of cell death, driving the metastasis of cancer cells. Identifying ferroptosis-related genes (FRGs) as prognostic factors will be critical to predict the outcomes of OS. This study aimed to explore the prognostic value of FRGs in OS and build a prognostic model to indirectly improve OS patients’ outcomes. Methods: OS data were downloaded from the TARGET database and 2 Gene Expression Omnibus datasets. Univariate Cox regression was conducted to assess FRGs. A risk score model basing on 5 FRGs was constructed via LASSO-Cox regression. Multivariate Cox regression analysis was used to determine the independent prognostic factors. The Nomogram model was built using independent prognostic factors. The relationship between the risk score and the immune cell infiltration was estimated by CIBERSORT, and the correlation between the risk score and immune checkpoints was also analyzed. Results: Based on the prognosis-related FRGs, we built a regression model: Risk score = (−0.01382853 × ACSL4) − (0.05371778 × HMOX1) − (0.02434655 × GPX4) − (0.16432810 × PRNP) − (0.15567120 × ATG7). OS patients with high risk score tended to suffer from poor prognosis, validated in 2 Gene Expression Omnibus datasets. The Nomogram model showed the combination of the risk score and the tumour-node-metastasis stage improved predictive effectiveness. The risk score was also related to immune cell infiltration and immune checkpoint expression. Conclusion: The risk score model based on 5 FRGs was a reliable prognostic predictive indicator for OS patients.

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“…130 Furthermore, other researchers utilizing similar methods have identified several genes associated with ferroptosis, with their findings converging on a pivotal gene, namely ZFP36. [131][132][133][134] ZFP36 is an RNA-binding protein targeted for degradation by FBXW7/CDC4 E3 ubiquitin ligase that plays a part in triggering ferroptosis in hepatic stellate cells (HSCs).…”

Section: Prognostic and Diagnostic Markers Associated With Ferroptosi...mentioning

confidence: 99%

Targeting ferroptosis in gastric cancer: Strategies and opportunities

Le,

Pan,

Zhang

et al. 2023

Immunological Reviews

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SummaryFerroptosis is a novel form of programmed cell death morphologically, genetically, and biochemically distinct from other cell death pathways and characterized by the accumulation of iron‐dependent lipid peroxides and oxidative damage. It is now understood that ferroptosis plays an essential role in various biological processes, especially in the metabolism of iron, lipids, and amino acids. Gastric cancer (GC) is a prevalent malignant tumor worldwide with low early diagnosis rates and high metastasis rates, accounting for its relatively poor prognosis. Although chemotherapy is commonly used to treat GC, drug resistance often leads to poor therapeutic outcomes. In the last several years, extensive research on ferroptosis has highlighted its significant potential in GC therapy, providing a promising strategy to address drug resistance associated with standard cancer therapies. In this review, we offer an extensive summary of the key regulatory factors related to the mechanisms underlying ferroptosis. Various inducers and inhibitors specifically targeting ferroptosis are uncovered. Additionally, we explore the prospective applications and outcomes of these agents in the field of GC therapy, emphasizing their capacity to improve the outcomes of this patient population.

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Identification and validation of a novel ferroptosis-related gene model for predicting the prognosis of gastric cancer patients

Cited by 10 publications

References 51 publications

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

Ferroptosis: A Double-Edged Sword in Gastrointestinal Disease

A five ferroptosis-related genes risk score for prognostic prediction of osteosarcoma

Targeting ferroptosis in gastric cancer: Strategies and opportunities

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