Identification and validation of autophagy‐related genes in exogenous sepsis‐induced acute respiratory distress syndrome

Xie, Yongpeng; Hu, Wenxia; Chen, Xiaobin; Ren, Panpan; Ye, Chongchong; Wang, Yanli; Luo, Jiye; Li, Xiaomin

doi:10.1002/iid3.691

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Transcriptome sequencing is a high-throughput sequencing of the sum of all RNA that could be transcribed by a specific cell in a certain functional state 55,56 . In this study, the high-throughput sequencing of the transcriptome of the pulmonary tissue of mice in control group and model group was used to explore the relevant mechanism of PF.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Zhang

Luo

Yuan

et al. 2023

Sci Rep

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Pulmonary fibrosis (PF) is a special type of pulmonary parenchymal disease, with chronic, progressive, fibrosis, and high mortality. There is a lack of safe, effective, and affordable treatment methods. Qilongtian (QLT) is a traditional Chinese prescription that is composed of Panax notoginseng, Earthworm, and Rhodiola, and shows the remarkable clinical curative effect of PF. However, the mechanism of QLT remains to be clarified. Therefore, we studied the effectivity of QLT in treating Bleomycin (BLM) induced PF mice. 36 C57BL/6 J mice were randomized into the control group, the model group, the low-, medium- and high-dose QLT group, and Pirfenidone group. After establishing a model of pulmonary fibrosis in mice, the control and model groups were infused with a normal saline solution, and the delivery group was infused with QLT. Pulmonary function in the mice from each group was detected. Pulmonary tissue morphologies and collagen deposition were stained by HE and Masson. The content of hydroxyproline (HYP) was detected by alkaline hydrolysis and the mRNA and protein expression of related genes in pulmonary tissues were detected by using q-PCR, ELISA, and Western blot. Our studies have shown that QLT significantly reduced the inflammatory injury, hydroxy-proline content, and collagen deposition of pulmonary tissue in BLM-induced PF mice and down-regulated the cytokine related to inflammation and fibrosis and PF expression on the mRNA and protein level in PF mice. To identify the mechanism of QLT, the Transcriptome was measured and the IL-17 signal pathway was screened out for further research. Further studies indicated that QLT reduced the mRNAs and protein levels of interleukin 17 (IL-17), c–c motif chemokine ligand 12 (CCL12), c-x-c motif chemokine ligand 5 (CXCL5), fos-like antigen 1 (FOSL1), matrix metalloproteinase-9 (MMP9), and amphiregulin (AREG), which are inflammation and fibrosis-related genes in the IL-17 signal pathway. The results indicated that the potential mechanism for QLT in the prevention of PF progression was by inhibiting inflammation resulting in the IL-17 signal pathway. Our study provides the novel scientific basis of QLT and represents new therapeutics for PF in clinical.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Zhang

Luo

Yuan

et al. 2023

Sci Rep

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“…ARDS is a complex syndrome characterized by heightened permeability of pulmonary capillary endothelial and alveolar epithelial cells, often leading to severe respiratory failure [ 33 ]. Bioinformatics research has pinpointed HIF-1α messenger ribonucleic acid (mRNA) as a potential autophagy-related gene associated with sepsis-associated ARDS [ 34 ]. Within endothelial cells, HIF-1α plays a pivotal role in supporting vascular repair and regression of inflammation in ARDS through the Forkhead Box Protein M1 (FOXM1) signaling pathway [ 35 , 36 ].…”

Section: Hypoxia-induced Modulation Of Hif-1α In Sepsismentioning

confidence: 99%

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Ruan,

Zhang,

Zhang

et al. 2024

Crit Care

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Sepsis is characterized by organ dysfunction resulting from a dysregulated inflammatory response triggered by infection, involving multifactorial and intricate molecular mechanisms. Hypoxia-inducible factor-1α (HIF-1α), a notable transcription factor, assumes a pivotal role in the onset and progression of sepsis. This review aims to furnish a comprehensive overview of HIF-1α's mechanism of action in sepsis, scrutinizing its involvement in inflammatory regulation, hypoxia adaptation, immune response, and organ dysfunction. The review encompasses an analysis of the structural features, regulatory activation, and downstream signaling pathways of HIF-1α, alongside its mechanism of action in the pathophysiological processes of sepsis. Furthermore, it will delve into the roles of HIF-1α in modulating the inflammatory response, including its association with inflammatory mediators, immune cell activation, and vasodilation. Additionally, attention will be directed toward the regulatory function of HIF-1α in hypoxic environments and its linkage with intracellular signaling, oxidative stress, and mitochondrial damage. Finally, the potential therapeutic value of HIF-1α as a targeted therapy and its significance in the clinical management of sepsis will be discussed, aiming to serve as a significant reference for an in-depth understanding of sepsis pathogenesis and potential therapeutic targets, as well as to establish a theoretical foundation for clinical applications. Graphical Abstract

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Suppression of miR-17 Alleviates Acute Respiratory Distress-associated Lung Fibrosis by Regulating Mfn2

Xu,

2024

CURR MED SCI

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Identification and validation of autophagy‐related genes in exogenous sepsis‐induced acute respiratory distress syndrome

Cited by 5 publications

References 30 publications

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

RETRACTED ARTICLE: Qilongtian ameliorate bleomycin-induced pulmonary fibrosis in mice via inhibiting IL-17 signal pathway

Unraveling the role of HIF-1α in sepsis: from pathophysiology to potential therapeutics—a narrative review

Suppression of miR-17 Alleviates Acute Respiratory Distress-associated Lung Fibrosis by Regulating Mfn2

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