Identification and validation of six proteins as marker for endemic nephropathy

Pešić, Ivan; Stefanović, Vladisav; Müller, Gerhard A.; Müller, Claudia; Čukuranović, Rade; Jahn, Olaf; Bojanić, Vladmila; Koziolek, Michael; Dihazi, Hassan

doi:10.1016/j.jprot.2011.05.020

Cited by 21 publications

(13 citation statements)

References 40 publications

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“…Alterations in proteins abundance, structure, or function, act as useful indicators of pathological abnormalities prior to development of clinical symptoms and such are often useful diagnostic and prognostic biomarkers (Issaq and Blonder, 2009). Proteomic techniques have been wildly applied to the study of cancer (Kumar et al, 2010;Pietrowska et al, 2009;Vydra et al, 2008), cardiovascular disease (Dardé et al, 2010;Yu et al, 2007), and other diseases (Araki et al, 2011;Cho et al, 2011;Kataria et al, 2011;Pešić et al, 2011;Terracciano et al, 2011). The application of proteomic investigations in the study of prostate cancer has aimed at improving the currently available Prostate-Specific Antigen (PSA) screening test.…”

Section: Environmental Proteomicsmentioning

confidence: 99%

Application of classic epidemiological studies and proteomics in research of occupational and environmental exposure to lead, cadmium and arsenic

Kossowska

Dudka

Gancarz

et al. 2013

International Journal of Hygiene and Environmental Health

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Section: Environmental Proteomicsmentioning

confidence: 99%

Application of classic epidemiological studies and proteomics in research of occupational and environmental exposure to lead, cadmium and arsenic

Kossowska

Dudka

Gancarz

et al. 2013

International Journal of Hygiene and Environmental Health

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“…17 The urinary proteomic analysis performed by Pešić et al validated six proteins as markers of BEN: alpha-1-microglobulin, beta-2-microglobulin, alpha 2-glycoprotein, mannose binding lectin-2, protection of telomeres protein-1, and superoxide dismutase (C-Zn). 18 Gluhovschi et al reported increased levels of urinary beta-2-microglobulin in inhabitants of the BEN area. 19 Comparing BEN patients with healthy controls, Stefanovic et al consider that urinary beta 2-microglobulin has higher sensitivity and specificity than alpha-1-microglobulin.…”

Section: Discussionmentioning

confidence: 98%

Familial versus environmental factors in Balkan endemic nephropathy in Mehedinti county, Romania, by means of albuminuria and tubular biomarkers: preliminary study

et al. 2014

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Introduction and aims: Balkan endemic nephropathy (BEN), a regional tubulointerstitial kidney disease encountered in South-Eastern Europe, with still undefined etiology and inexorable evolution towards end stage renal disease, raises the question of the relative contribution of family and environmental factors in its etiology. In order to evaluate the intervention of these factors, markers of tubular injury have been assessed, this lesion being considered an early renal involvement in BEN. Methods: The paper studies relatives of BEN patients currently included in dialysis programmes (for involvement of the family factor) and their neighbors (for involvement of environmental factors) and analyzes them with regard to tubular injury by means of tubular biomarkers (N-acetyl-beta-D-glucosaminidase-NAG and alpha-1-microglobulin), and albuminuria. At the same time, glomerular filtration rate (GFR) (CKD-EPI) was measured. It is considered that, in order to acquire the disease, one should have lived for 20 years in the BEN area. The relatives have been classified according to this criterion. Results: More evident tubular injury was found in the neighbors of BEN patients living for more than 20 years in the endemic area, which argues in favor of environmental factors. Higher levels of urinary alpha-1-microglobulin and albumin in relatives of BEN patients who had been living for more than 20 years in the area than in relatives with a residence under 20 years, plead for the same hypothesis. GFR was lower in persons who had been living for more than 20 years in the BEN area (neighbors and relatives). Conclusions: Environmental factors could be more important in BEN than family factors.

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“…Most of the urinary proteins detected in this study were associated with host renal failure such as acute renal transplant rejection [29,30], glomerular disease [31,32,36], diabetes mellitus type 2 [33,35], chronic kidney disease [34], pancreatitis [31], and endemic nephropathy [37]. The proteins identified in our study, except for leptospiral HADH, are biomarkers known to be involved in renal failure, but are not specific for Leptospira infection.…”

Section: Discussionmentioning

confidence: 99%

Identification of leptospiral 3-hydroxyacyl-CoA dehydrogenase released in the urine of infected hamsters

et al. 2014

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BackgroundLeptospirosis is a global zoonosis caused by pathogenic Leptospira. The non-specific clinical signs and symptoms of leptospirosis lead to its misdiagnosis. To date, there is still no reliable rapid test kit that can accurately diagnose leptospirosis at bedside or in field. In this research, with the ultimate goal of formulating a rapid and accurate diagnostic tool for leptospirosis, we aimed to identify leptospiral proteins excreted in urine of infected hamsters, which are thought to mimic Weil’s disease.ResultsHamsters were subcutaneously infected with leptospires, and the general attributes of urine as well as the proteins excreted in it were examined. Some leptospiral proteins were found to be excreted in the urine from the early phase of infection. The most important finding of this study was the detection of the lipid-metabolizing enzyme, 3-hydroxyacyl-CoA dehydrogenase (HADH), before the onset of illness, when leptospires were not yet detected in the urine of infected hamsters.ConclusionsThis is the first report on the detection of leptospiral HADH in the host urine, which may be a possible candidate leptospiral antigen that can be used in the early diagnosis of human and animal leptospirosis.

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Identification and validation of six proteins as marker for endemic nephropathy

Cited by 21 publications

References 40 publications

Application of classic epidemiological studies and proteomics in research of occupational and environmental exposure to lead, cadmium and arsenic

Application of classic epidemiological studies and proteomics in research of occupational and environmental exposure to lead, cadmium and arsenic

Familial versus environmental factors in Balkan endemic nephropathy in Mehedinti county, Romania, by means of albuminuria and tubular biomarkers: preliminary study

Identification of leptospiral 3-hydroxyacyl-CoA dehydrogenase released in the urine of infected hamsters

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